belimumab suppliers
belimumab
- CAS:
- 356547-88-1
- MF:
- MW:
- 0
Suppliers by country/region
Company Type
Properties
- storage temp.
- Store at 4°C, do not freeze
- form
- Solid
- color
- White to off-white
Safety Information
Use
Belimumab was approved by the U.S. FDA in March 2011 for treatment of patients with active, autoantibody-positive, systemic lupus erythematosus (SLE). Belimumab is a human sequence monoclonal antibody that binds to human B lymphocyte stimulator protein (BLys; also known as BAFF, THANK, TALL-1, TNFSF13B, and zTNF4), which is overexpressed in SLE patients. BLys is expressed on the cell surface of monocytes, macrophages, and monocyte-derived dendritic cells and is cleaved to form a soluble cytokine that stimulates cell proliferation and antibody secretion in B lineage cells that express the BLys receptor BAFF-R (also known as BR-3). The precise function of two additional BLys receptors, TACI and BCMA, is less clear. Belimumab inhibits BLys interaction with these three receptors leading to measurable reductions in autoantibodies, such as anti-dsDNA, and specific circulating B cell lineage compartments including antibody producing plasma cells. Belimumab was discovered by screening molecules from a phage display library of human single-chain Fv sequences for BLys binding and functional blocking, followed by optimization of the lead through the introduction of variant residues in VH CDR3.
14 supplier list of "belimumab"
- Product Name:Belimumab (anti-TNFSF13B)
- Products Intro:Purity: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human I | Package: $57.9/1mg;$117.9/5mg;$177.9/10mg;Bulk package | CustNote: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
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5MG$500.57
- Product Name:BELIMUMAB
- Products Intro:Brand:Acccorporation | OriginalID:API0008201 | Purity:95.00%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Belimumab
- Products Intro:Purity: 95%
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Belimumab;LymphoStat B
- Products Intro:Purity: SDS-PAGE:98.4%;SEC-HPLC:98.4% | Package: 详见官网
- Company Type: Trader
- Country/Region: CHINA