BI-6C9 manufacturers and suppliers

BI-6C9 suppliers

BI-6C9

CAS:: 791835-21-7

MF:: C23H25N3O4S2

MW:: 471.59

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Properties

Density: 1.36±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility: DMSO: 24 mg/mL, soluble

form: solid

pka: 11.58±0.50(Predicted)

color: off-white

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

WGK Germany: 3

Use

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.

You can find BI-6C9 suppliers, manufacturers, and distributors from countries such as United States, China and the Switzerland here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.