BI-D1870 suppliers
BI-D1870
- CAS:
- 501437-28-1
- MF:
- C19H23F2N5O2
- MW:
- 391.42
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Properties
- Boiling point:
- 579.3±60.0 °C(Predicted)
- Density
- 1.297
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 15 mg/ml)
- form
- Off-white solid.
- pka
- 7.68±0.36(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H227
- Precautionary statements
- P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
- HS Code
- 2933599590
Use
The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively). At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2. BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.
96 supplier list of "BI-D1870"
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