CCG-100602 suppliers
CCG-100602
- CAS:
- 1207113-88-9
- MF:
- C21H17ClF6N2O2
- MW:
- 478.82
Suppliers by country/region
Properties
- storage temp.
- -20°C
- solubility
- ≤0.2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- powder
- color
- white to beige
Safety Information
Use
The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-100602 is a CCG-1423 analog developed for improved selectivity, potency, and attenuated cytotoxicity relative to its parent compound. CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 μM. At 100 μM, CCG-100602 demonstrates 72% inhibition of PC-3 cell invasion into a Matrigel model of metastasis, exhibiting an efficacy:toxicity profile superior to that of CCG-1423 at 10 μM.[Cayman Chemical]
30 supplier list of "CCG-100602"
- Product Name:CCG-100602
- Products Intro:Brand:sigma aldrich | Product Number:SML2292 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: INDIA
- Product Name:CCG-100602
- Company Type: Trader
- Country/Region: CHINA
- Product Name:CCG-100602
- Company Type: Trader
- Country/Region: CHINA