Dacomitinib (PF299804) suppliers
Dacomitinib (PF299804)
- CAS:
- 1110813-31-4
- MF:
- C24H25ClFN5O2
- MW:
- 469.94
Suppliers by country/region
Company Type
Properties
- Melting point:
- 184-187°C
- Boiling point:
- 665.7±55.0 °C(Predicted)
- Density
- 1.344
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- White solid.
- pka
- 12.05±0.43(Predicted)
- color
- White to Pale Yellow
- InChIKey
- LVXJQMNHJWSHET-AATRIKPKSA-N
- SMILES
- C(NC1C(OC)=CC2C(C=1)=C(NC1=CC=C(F)C(Cl)=C1)N=CN=2)(=O)/C=C/CN1CCCCC1
- CAS DataBase Reference
- 1110813-31-4
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
- HS Code
- 29335990
Use
Dacomitibib (Dacomitinib, PF299804) is an effective and irreversible pan-ErbB inhibitor that is most effective in EGFR, with an IC50 of 6 nM. It is also highly effective in NSCLCs that carries EGFR or ERBB2 mutants (against Gefitinib) and EGFR T790M mutant. Phase 2. Dacomitinib is taken orally once-daily. It is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. Dacomitinib targets multiple receptors of the HER pathway, whereas currently marketed HER-1 (EGFR) inhibitors for non-small cell lung cancer (NSCLC) target only one receptor in this pathway,developed by Pfizer.
237 supplier list of "Dacomitinib (PF299804)"
- Product Name:Dacomitinib
- Products Intro:Package: 25g; 50g; 250g;100g; 500g; 1kg; 5kg; 10kg; 25kg
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: active pharmaceutical ingredients (APIs),Intermediates,pharmaceutical excipients,veterinary chemicals,packaging materials
- Product Name:Dacomitinib
- Products Intro:Purity: 0.98 | Package: 1kg,10kg, 25kg per bag or drum
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: Vilanterol intermediates,Bilastine intermediates,Glycopyrrolate Bromide intermediates,Piperidine intermediates,Pyridine intermediates
- Product Name:Dacomitinib
- Products Intro:Purity: 0.99 | Package: 1G；100G;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1,4-Naphthalenedicarboxylic acid,Pamoic acid,Enfumafungin,6-bromonaphthalen-2-amine,Fusidic acid
$0.00/ 1kg
- Product Name:Dacomitinib (PF299804)
- Products Intro:Purity: 0.99|Package: 1kg;0.00;USD
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: lead acetate,Lead oxide,PMK ethyl glycidate,BMK Glycidic Acid,Diethyl(phenylacetyl)malonate
$0.00-0.00 / 10g
- Product Name:Dacomitinib（PF299804）
- Products Intro:Purity: 99% HPLC|Package: 10g;0.00;USD|100g;0.00;USD|500g;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Semaglutide,Tirzepatide,Retatrutide,Cholecystokinin,Cagrilintide
$0.00/ 1g
- Product Name:Dacomitinib
- Products Intro:Purity: 98% HPLC | Package: 1g
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Inosine pranobex,Probenecid,Sodium Ceftiofur,3-O-Ethyl-L-ascorbic acid,benzhexol hydrochloride
$60.00-600.00 / 1kg
- Product Name:Dacomitinib (PF299804)
- Products Intro:Purity: 0.99|Package: 1kg;60.00;USD|10kg;600.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Fine Chemical,API,Raw Material,Pharmaceutical Compounds,Others
$50.00/ 1kg
- Product Name:Dacomitinib
- Products Intro:Purity: 99% | Package: 1kg;50USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediates,Peptides,Organic Chemical,Sarm Product,Pharmaceutical Chemical
$0.00/ 1kg
- Product Name:Dacomitinib (PF299804)
- Products Intro:Purity: 99% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Dacomitinib
- Products Intro:Purity: NLT 98% | Package: 1G;1KG;100KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0