Dexamethasone 21-phosphate disodium salt manufacturers and suppliers

Dexamethasone 21-phosphate disodium salt suppliers

Properties

Melting point:: 233-235 °C

alpha: D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124

storage temp.: 2-8°C

solubility: H₂O: 50 mg/mL, clear, faintly yellow

form: White Powder

color: white to off-white

PH: pH(10g/l, 25℃) : 7.5～10.5

Water Solubility: Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.

Merck: 13,2960

BRN: 6473066

Stability:: Hygroscopic

InChIKey: PLCQGRYPOISRTQ-FCJDYXGNSA-L

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H361d

Precautionary statements: P201-P301+P312+P330-P308+P313

Hazard Codes: Xn

Risk Statements: 22-40-63

Safety Statements: 36/37/39

WGK Germany: 3

RTECS: TU4056000

F: 3-10

TSCA: Yes

HS Code: 2937220000

Use

Dexamethasone 21-phosphate disodium salt is a system glucocorticoid with anti-inflammatory properties, is the pro-drug which is converted to dexamethasone in vivo. It stimulates uptake of glutamine in the cerebral cortex and induces apoptosis. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. It is freely soluble in water, slightly soluble in ethanol, and insoluble in chloroform and in ether. It is an inhibitor of the sodium phosphate symporter and GR activator. Additionally, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

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