EFONIDIPINE suppliers
EFONIDIPINE
- CAS:
- 111011-76-8
- MF:
- C34H38N3O7P.C2H6O.ClH
- MW:
- 714.19
Suppliers by country/region
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Properties
- Melting point:
- 151° (dec)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO : 25 mg/mL (35.01 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- color
- Light yellow to yellow
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501
Use
Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP) calcium channel blocker to reach the market, it functions by binding to the DHP receptors on voltage-dependent calcium channels to cause diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are very slow in onset and long-lasting in all types of experimentally hypertensive models and the agent is reported to exhibit an improved side effect profile compared with other drugs of the same class. This may be explained by the slow and long-lasting inhibition of transmembrane Ca+2 uptake, which is accompanied by its very slow binding to and dissociation from the DHP receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may suppress the development of atherosclerosis without affecting the plasma lipids. Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been reported.
75 supplier list of "EFONIDIPINE"
$0.00/ 1G
- Product Name:Efonidipine
- Products Intro:Purity: 98%min | Package: 1G
- Company Type: Trader
- Country/Region: CHINA
-
10 mg$115.0050 mg$485.00
- Product Name:5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-[phenyl(phenylmethyl)amino]ethyl ester hydrochloride monoethanolate
- Products Intro:Brand: Tocris Bioscience | Product Number: 3733 | Purity: ≥99% (HPLC)
- Company Type: Trader
- Country/Region: UNITED KINGDOM