FERULIC ACID METHYL ESTER manufacturers and suppliers

FERULIC ACID METHYL ESTER suppliers

Properties

Melting point:: 62-65°C

Boiling point:: 163 °C(Press: 1 Torr)

Density: 1.204±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Sparingly)

form: Solid

pka: 8.88±0.18(Predicted)

color: White to Off-White

Water Solubility: Slightly soluble in water.

LogP: 2.209 (est)

CAS DataBase Reference: 2309-07-1(CAS DataBase Reference)

NIST Chemistry Reference: 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester(2309-07-1)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements: 36/37/38

Safety Statements: 26-36/37/39

RTECS: GD9470000

HS Code: 2918999090

Use

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid methyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 74.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). Ferulic acid methyl ester, at 10-25 μg/ml, inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.

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