FILGRASTIM manufacturers and suppliers

FILGRASTIM suppliers

FILGRASTIM

CAS:: 121181-53-1

MF:: W99

MW:: 0

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Properties

storage temp.: -70°C

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501

HS Code: 3002905150

Toxicity: LD50 oral in rat: > 3mg/kg

Use

Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced.

You can find FILGRASTIM suppliers, manufacturers, and distributors from countries such as China, United States and the Europe here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.