GDC-0068 suppliers
GDC-0068
- CAS:
- 1001264-89-6
- MF:
- C24H32ClN5O2
- MW:
- 458
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Properties
- Melting point:
- >106°C (dec.)
- Boiling point:
- 669.4±55.0 °C(Predicted)
- Density
- 1.254
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Soluble in DMSO.
- pka
- 13.11±0.40(Predicted)
- form
- Solid
- color
- peachy
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Use
DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively.GDC-0068 is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
111 supplier list of "GDC-0068"
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