Hydralazine hydrochloride manufacturers and suppliers

Hydralazine hydrochloride suppliers

Properties

Melting point:: 273°C

Boiling point:: 322.13°C (rough estimate)

Density: 1.2961 (rough estimate)

refractive index: 1.6110 (estimate)

storage temp.: 2-8°C

solubility: Soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride

form: Solid

color: White to Almost white

PH: pH (20g/l, 25℃) : 3.5～4.5

Water Solubility: Soluble in water. Slightly soluble in diethyl ether and alcohol.

Merck: 14,4763

BRN: 3568329

BCS Class: 3

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301-H315-H319-H335

Precautionary statements: P301+P330+P331+P310-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26-36/37/39-45

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: TH9000000

TSCA: Yes

HazardClass: 6.1

PackingGroup: III

HS Code: 29339900

Toxicity: LD50 oral in rat: 280mg/kg

Use

Hydralazine hydrochloride is useful in the treatment ofmoderate-to-severe hypertension. It is often used in conjunctionwith less potent antihypertensive agents, becauseside effects occur frequently when it is used alone in adequatedoses. In combinations, it can be used in lower andsafer doses. Its action appears to be centered on the smoothmuscle of the vascular walls, with a decrease in peripheralresistance to blood flow. This results in increased bloodflow through the peripheral blood vessels. It also has theunique property of increasing renal blood flow, an importantconsideration in patients with renal insufficiency.Hydralazine hydrochloride acts on vascular smooth muscleto cause relaxation. Its mechanism of action is unclear. Itinterferes with Ca2+ entry andCa2+release from intracellularstores and reportedly causes activation of guanylate cyclase,resulting in increased levels of cGMP. All of thesebiochemical events can cause vasodilation.

You can find Hydralazine hydrochloride suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.