Hydrochlorothiazide manufacturers and suppliers

Hydrochlorothiazide suppliers

Properties

Melting point:: 273 °C

Boiling point:: 577.0±60.0 °C(Predicted)

Density: 1.6761 (rough estimate)

refractive index: 1.6100 (estimate)

Flash point:: 9℃

storage temp.: 2-8°C

solubility: Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides

pka: 7.9, 9.2(at 25℃)

form: solid

color: White to Off-White

Odor: wh. or pract. wh. cryst. powd., odorless

Water Solubility: 722mg/L(25 ºC)

λmax: 318nm(H2O)(lit.)

Merck: 14,4781

BRN: 625101

BCS Class: 3,4

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: JZUFKLXOESDKRF-UHFFFAOYSA-N

LogP: -0.070

CAS DataBase Reference: 58-93-5(CAS DataBase Reference)

NIST Chemistry Reference: 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide(58-93-5)

IARC: 2B (Vol. 50, 108) 2016

EPA Substance Registry System: Hydrochlorothiazide (58-93-5)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

Hazard Codes: Xi,T,F,Xn

Risk Statements: 22-42/43-36/38-23/25-36/37/38-39/23/24/25-23/24/25-11

Safety Statements: 22-24-36/37-45-33-16-7-36/37/39-27-26

RIDADR: UN 1230 3/PG 2

WGK Germany: 2

RTECS: DK9100000

Hazard Note: Irritant

TSCA: Yes

HS Code: 29350090

Hazardous Substances Data: 58-93-5(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 590 i.v.; >8000 orally (Piala)

Use

Hydrochlorothiazide is a kind of thiazide diuretic drugs with moderate diuretic effect. It exert is diuretic effect through acting on the medullary ascending limb cortical segment, inhibiting the active re-absorption of Cl-and passive absorption of Na+ at this site. In addition, the product also has a hypotensive effect and anti-diuretic effect. It is suitable for treating a variety of edema, particularly for cardiogenic edema. It can also be used as antihypertensive agents, for treatment light, medium hypertension. It also has certain efficacy in treating diabetes insipidus, and idiopathic hypercalciuria. Commonly used thiazide diuretics include hydrochlorothiazide, chlorthalidone, indapamide and the like.

You can find Hydrochlorothiazide suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.