Hydroxypropyl cellulose manufacturers and suppliers

Hydroxypropyl cellulose suppliers

Properties

Melting point:: 371.06 °C

Density: 0.5 g/mL at 25 °C (lit.)

refractive index: 1.5600

storage temp.: Room Temperature

solubility: polar oganic solvents: soluble

form: powder

color: White to light cream

PH Range: 5.0 - 8.5

PH: pH (20g/l, 25℃) : 5.0～7.5

Odor: at 100.00?%. odorless

Water Solubility: Soluble in polar organic solvents, in water at room temperature.Soluble in water, methyl alcohol, ethyl alcohol and other organic solvents.

Merck: 14,4841

Stability:: Stable. Incompatible with strong oxidizing agents. Combustible.

InChI: InChI=1S/CH4/h1H4

InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N

SMILES: C

CAS DataBase Reference: 9004-64-2

EPA Substance Registry System: Cellulose, 2-hydroxypropyl ether (9004-64-2)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H335-H332-H319-H315

Precautionary statements: P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362

Safety Statements: 24/25

WGK Germany: 1

RTECS: NF9050000

F: 3-10

Autoignition Temperature: 752 °F

TSCA: Yes

HS Code: 39129000

Use

Hydroxypropyl cellulose is widely used in oral and topical pharmaceutical formulations. In oral products, hydroxypropyl cellulose is primarily used in tableting as a binder,film-coating,and extended-release-matrix former. Concentrations of hydroxypropyl cellulose of 26% w/w may be used as a binder in either wet-granulation or dry, direct compression tableting processes. Concentrations of 1535% w/w of hydroxypropyl cellulose may be used to produce tablets with an extended drug release. The release rate of a drug increases with decreasing viscosity of hydroxypropyl cellulose. The addition of an anionic surfactant similarly increases the viscosity of hydroxypropyl cellulose and hence decreases the release rate of a drug. Blends of hydroxypropyl cellulose and other cellulosic polymers have been used to improve wet granulation characteristics and tableting characteristics, as well as to achieve better control and manipulation of the rate of drug release. As an alternative technology to wet granulation, dry granulation and direct compression of hydroxypropyl cellulose formulations have been reported to exhibit acceptable tableting and flow characteristics for application in extended-release matrix tablets. Typically, a 5% w/w solution of hydroxypropyl cellulose may be used to film-coat tablets. Aqueous solutions containing hydroxypropyl cellulose together with an amount of methyl cellulose or ethanolic solutions have been used. Stearic acid or palmitic acid may be added to ethanolic hydroxypropyl cellulose solutions as plasticizers. Environmental concerns have limited the use of ethanol in film coating solutions. A low-substituted hydroxypropyl cellulose is used as a tablet disintegrant; see Hydroxypropyl Cellulose, Low-substituted. Hydroxypropyl cellulose is also used in microencapsulation processes and as a thickening agent. In topical formulations, hydroxypropyl cellulose is used in transdermal patches and ophthalmic preparations. Hydroxypropyl cellulose is also used in cosmetics and in food products as an emulsifier and stabilizer.

You can find Hydroxypropyl cellulose suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.