LX-4211 manufacturers and suppliers

LX-4211 suppliers

LX-4211

CAS:: 1018899-04-1

MF:: C21H25ClO5S

MW:: 424.94

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Properties

Boiling point:: 607.9±55.0 °C(Predicted)

Density: 1.37±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM)
Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM)

pka: 12.87±0.70(Predicted)

form: Powder

color: White to off-white

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351-H373

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P260-P314-P501

Use

Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%. Sotagliflozin synthesis Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%. Sotagliflozin synthesis

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