Mirin suppliers
Mirin
- CAS:
- 299953-00-7
- MF:
- C10H8N2O2S
- MW:
- 220.25
Suppliers by country/region
Company Type
Properties
- Melting point:
- 295-297 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 441.6±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- Reddish orange powder
- pka
- 9.15±0.30(Predicted)
- color
- red to orange
- Sensitive
- Moisture Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- Hazard Codes
- Xi
- Risk Statements
- 36
- Safety Statements
- 26
- WGK Germany
- 3
Use
The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical]
25 supplier list of "Mirin"
- Product Name:MRN-ATMPathwayInhibitor,Mirin-CAS299953-00-7-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:475954 | Purity:TheMRN-ATMPathwayInhibitor,Mirin,alsoreferencedunderCAS299953-00-7,controlsthebi
- Company Type: Trader
- Country/Region: INDIA