ML216 manufacturers and suppliers

ML216 suppliers

ML216

CAS:: 1430213-30-1

MF:: C15H9F4N5OS

MW:: 383.32

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Properties

Density: 1.583±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)

pka: 6.40±0.50(Predicted)

form: powder

color: light orange to dark orange

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301-H413

Precautionary statements: P273-P301+P310+P330

Hazard Codes: T

Risk Statements: 25

Safety Statements: 45

RIDADR: UN 2811 6.1 / PGIII

WGK Germany: 3

Use

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.[Cayman Chemical]

You can find ML216 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the Germany here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.