N-(3-Oxotetradecanoyl)-L-homoserine lactone manufacturers and suppliers

N-(3-Oxotetradecanoyl)-L-homoserine lactone suppliers

N-(3-Oxotetradecanoyl)-L-homoserine lactone

CAS:: 177158-19-9

MF:: C18H31NO4

MW:: 325.44

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Properties

Melting point:: 96-97 °C(Solv: ethyl acetate (141-78-6))

Boiling point:: 537.3±50.0 °C(Predicted)

Density: 1.04±0.1 g/cm3(Predicted)

storage temp.: −20°C

solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml

form: A crystalline solid

pka: 11.21±0.46(Predicted)

color: White to off-white

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319

Precautionary statements: P305+P351+P338

WGK Germany: 3

Use

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. It appears later than shorter acyl chain AHLs in developing biofilms and, like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, which in turn, inhibits biofilm formation.

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