N-ACETYL-4-BENZOQUINONE IMINE suppliers
N-ACETYL-4-BENZOQUINONE IMINE
- CAS:
- 50700-49-7
- MF:
- C8H7NO2
- MW:
- 149.15
Suppliers by country/region
Properties
- Melting point:
- 74-75
- Boiling point:
- 255.6±43.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -70°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly)
- form
- Solid
- pka
- -3.37±0.20(Predicted)
- color
- Pale Yellow to Very Dark Red
- Stability:
- Temperature, Moisture, Light, and Oxygen Sensitive
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
- WGK Germany
- 3
- RTECS
- AC6960000
- HS Code
- 2902110000
- Toxicity
- LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson)
Use
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
68 supplier list of "N-ACETYL-4-BENZOQUINONE IMINE"
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