Nateglinide suppliers
Nateglinide
- CAS:
- 105816-04-4
- MF:
- C19H27NO3
- MW:
- 317.42
Suppliers by country/region
Company Type
Properties
- Melting point:
- 137-141°C
- alpha
- D20 -9.4° (c = 1 in methanol)
- Boiling point:
- 527.6±39.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: >5mg/mL
- form
- solid
- pka
- 3.61±0.10(Predicted)
- color
- white to off-white
- Merck
- 14,6428
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 24/25-36
- WGK Germany
- 3
- RTECS
- SQ7318950
- HS Code
- 29242990
- Toxicity
- LD50 orally in rats: >2.0 g/kg (Hasegawa)
Use
Nateglinide is a N-acylated D-phenylalanine marketed in Japan as novel orally active insulinotropic agent for the treatment of type-2 diabetes mellitus. It belongs to the class of nonsulfonylureas and shows some structural similarity to repaglinide, the only other representative in this family. In single pancreatic beta-cells isolated from rats, Nateglinide was found to specifically block the ATP-sensitive K+ channel resulting in an increase in intracellular calcium concentration. This primary action would underlie the mechanism by which Nateglinide markedly stimulates or potentiates, depending on glucose concentrations, insulin secretion from pancreatic beta-cells. Clinical studies demonstrated a good safety profile with a low potential for hypoglycemia.
352 supplier list of "Nateglinide"
$0.00/ 25KG
- Product Name:Nateglinide
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: carbomer,lead acetate,phenylacetamide,Xylazine,Xylazine hcl
$2.00/ 1kg
- Product Name:Nateglinide
- Products Intro:Purity: 99% | Package: 1kg;2USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$1.10/ 1g
- Product Name:Nateglinide
- Products Intro:Purity: 99.9%|Package: 1g;1.1USD
- Company Type: Trader
- Country/Region: CHINA