NPS 2390 suppliers
NPS 2390
- CAS:
- 226878-01-9
- MF:
- C19H21N3O
- MW:
- 307.39
Suppliers by country/region
Properties
- Boiling point:
- 542.4±30.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble to 50 mM in DMSO and to 50 mM in ethanol
- form
- Powder
- pka
- 11.53±0.20(Predicted)
- color
- White to light yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
Use
Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-selective antagonist, [3H]R214127, in rat cerebellum.
32 supplier list of "NPS 2390"
- Product Name:NPS 2390
- Products Intro:Purity: >=99%(HPLC) | Package: $73.9/5mg;$117.9/10mg;$226.9/25mg;$395.9/50mg;$642.9/100mg;$1446.9/250mg;Bulk pa | CustNote: 99%(HPLC)
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
![NPS2390](/images/pro-3.jpg)
-
50mg$604.00
- Product Name:NPS2390
- Products Intro:Brand:csnpharm | Product Number:CSN23007
- Company Type: Trader
- Country/Region: UNITED STATES
![NPS2390](/images/pro-3.jpg)
-
100mg$192.00250mg$325.00
- Product Name:NPS2390
- Products Intro:Brand:aaronchem | Product Number:AR00BGQW | Purity:98%
- Company Type: Trader
- Country/Region: UNITED STATES