NVP-BEZ 235 suppliers
NVP-BEZ 235
- CAS:
- 915019-65-7
- MF:
- C30H23N5O
- MW:
- 469.55
Suppliers by country/region
Company Type
Properties
- Melting point:
- 288-289°C
- Boiling point:
- 701.0±70.0 °C(Predicted)
- Density
- 1.299
- storage temp.
- Refrigerator
- solubility
- Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
- form
- White powder.
- pka
- 6.41±0.20(Predicted)
- color
- White or off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Use
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]
161 supplier list of "NVP-BEZ 235"
$20.00-15.00 / 1kg
- Product Name:BEZ-235
- Products Intro:Purity: 99%|Package: 1kg;20.00;USD|10kg;18.00;USD|100kg;15.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Povidone Iodine,Lenvatinib mesylate,1,2,3-Triacetyl-5-deoxy-D-ribose,Diethyl L-glutamate hydrochloride,Pregabalin
$1.00/ 1KG
- Product Name:NVP-BEZ 235
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information