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ChemicalBook >> CAS DataBase List >>PF-03814735

PF-03814735 suppliers

PF-03814735

CAS:
942487-16-3
MF:
C23H25F3N6O2
MW:
474.48

Properties

Melting point:
181-183°C
Density 
1.443
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
15.02±0.46(Predicted)
color 
white to beige

Safety Information

Symbol(GHS) 
GHS hazard pictograms
GHS07
Signal word 
Warning
Hazard statements 
H315-H319-H335
Precautionary statements 
P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
WGK Germany 
3

Use

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.[Cayman Chemical]

112 supplier list of "PF-03814735"

  • 1g$1
  • Product Name:PF-03814735
  • Products Intro:Purity: 0.99, AD68|Package: 1g;1USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Methyl 3-amino-2-fluorobenzoate
  • Product Name:PF-03814735
  • Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:PF-03814735 PF03814735
  • Products Intro:Purity: 99% | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: sarms
  • Product Name:PF-03814735;PF03814735;PF 03814735
  • Products Intro:Package: 1 mL * 10mM (in DMSO);10 mg;2 mg;25 mg;5 mg;50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
  • Company Type: Reagent
  • Country/Region: UNITED STATES
  • Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
  • Product Name:PF-03814735
  • Products Intro:Purity: 99% | Package: 1KG;25kg;200kg;1000kg Jessica | CustNote: g-kg-tons,free sample is available.Bottle/drum/IBC.Advantage products,new batches,regular stock, ready for shipment.
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Chemical raw materials,Organic raw materials,Petrochemicals,Chemical reagents,Intermediates
N-(2-((1S,4R)-6-((4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide
  • Product Name:N-(2-((1S,4R)-6-((4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide
  • Products Intro:Purity: 95%+ | Package: 1g;5g;10g;25g;50g;100g; | CustNote: accept Custom Synthesis Services, support large packing
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: cof,mof
  • Product Name:PF-03814735
  • Products Intro:Purity: 98% | Package: $24.9/1mg;$102.9/5mg;$165.9/10mg;$711.9/50mg;Bulk package | CustNote: 98%
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
  • Product Name:2-(4-Bromophenyl)-1-phenyl-1H-benzimidazole
  • Products Intro:Purity: 0.99 | Package: 100g;1kg;5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Isopropyl alcohol,Polyvinyl chlorid,Dodecylbenzenesulphonic acid,Dimethyl Sulfoxide,Titanium Dioxide
  • Product Name:PF-03814735
  • Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A916762
  • Company Type: Reagent
  • Country/Region: CHINA
  • 5mg$94.20
    25mg$370.00
  • Product Name:PF-03814735
  • Products Intro:Brand: Sigma-Aldrich | Product Number: PZ0218 | Purity: ≥98% (HPLC)
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Main Products: cof,mof
You can find PF-03814735 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the The Netherlands here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

PF-03814735 Related Search:

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