Phenytoin sodium manufacturers and suppliers

Phenytoin sodium suppliers

Properties

storage temp.: Inert atmosphere,Room Temperature

solubility: aqueous base: soluble

form: Crystalline Powder

color: White to almost white

Merck: 14,7322

BCS Class: 2

Stability:: Hygroscopic

InChIKey: FJPYVLNWWICYDW-UHFFFAOYSA-M

CAS DataBase Reference: 630-93-3(CAS DataBase Reference)

EPA Substance Registry System: Diphenylhydantoin sodium (630-93-3)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H317-H361

Precautionary statements: P201-P202-P280-P301+P312-P302+P352-P308+P313

Hazard Codes: Xn

Risk Statements: 22-43-62-63

Safety Statements: 22-36/37/39-45

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: MU1400000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29332100

Toxicity: LD50 orally in mice: 490 mg/kg (Fink, Swinyard)

Use

Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.

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