Pirinixic Acid Aminothiazole manufacturers and suppliers

Pirinixic Acid Aminothiazole suppliers

Pirinixic Acid Aminothiazole

CAS:: 1492060-44-2

MF:: C25H25ClN4O2S2

MW:: 513.07

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Properties

Boiling point:: 697.1±65.0 °C(Predicted)

Density: 1.39±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: ≤20mg/ml in DMSO;25mg/ml in dimethyl formamide

form: crystalline solid

pka: 3.02±0.21(Predicted)

Safety Information

Use

Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 μM, respectively). It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms. Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.[Cayman Chemical]

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