Posaconazole manufacturers and suppliers

Posaconazole suppliers

Properties

Melting point:: 170-1720C

Boiling point:: 850.7±75.0 °C(Predicted)

Density: 1.36±0.1 g/cm3(Predicted)

Flash point:: 9℃

storage temp.: -20°C

solubility: Chloroform (Slightly), Methanol (Slightly)

pka: 14.72±0.20(Predicted)

form: powder

color: white to beige

optical activity: [α]/D -24 to -32°, c = 1.0 in chloroform-d

Merck: 14,7602

InChIKey: RAGOYPUPXAKGKH-XAKZXMRKSA-N

SMILES: [C@]1(OC[C@@H](COC2C=CC(N3CCN(C4=CC=C(N5C=NN([C@@H](CC)[C@@H](O)C)C5=O)C=C4)CC3)=CC=2)C1)(CN1N=CN=C1)C1=CC=C(F)C=C1F |&1:0,3,22,25,r|

CAS DataBase Reference: 171228-49-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS02,GHS06,GHS08

Signal word: Danger

Hazard statements: H225-H301+H311+H331-H370

Precautionary statements: P210-P260-P280-P301+P310-P311

Hazard Codes: F,T

Risk Statements: 11-23/24/25-39/23/24/25

Safety Statements: 7-16-36/37-45

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 3

RTECS: XZ5481020

HS Code: 3204.90.0000

Hazardous Substances Data: 171228-49-2(Hazardous Substances Data)

Use

Posaconazole, launched in the UK, is the newest member of the azole class of antifungal agents to reach the market. It is indicated for the treatment and prophylaxis of a range of invasive fungal infections, including aspergillosis,fusariosis, chromoblastomycosis, mycetoma, and coccidiomycosis in patients who are refractory to, or intolerant of, standard therapy with amphotericin B and/or itraconazole. In the US, it is approved for the prophylaxis of invasive Aspergillus and Candida infections in patients 13 years of age who are at high risk of developing these infections due to being severely immunocompromised. Additionally, it is approved for the treatment of oropharyngeal candidiasis. Posaconazole has an expanded spectrum of activity over other members of the azole antifungals. In addition to potent activity against refractory cases of aspergillosis and fluconazole-resistant Candida, it demonstrates activity against Zygomycetes.

You can find Posaconazole suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.