Progabide manufacturers and suppliers

Progabide suppliers

Progabide

CAS:: 62666-20-0

MF:: C17H16ClFN2O2

MW:: 334.77

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Properties

Melting point:: 133-135°; mp 142.5° (Kaplan, J. Med. Chem.)

Boiling point:: 525.4±50.0 °C(Predicted)

Density: 1.2822 (estimate)

storage temp.: 2-8°C

solubility: Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)

form: Solid

pka: pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)

color: Light Yellow to Yellow

Water Solubility: 37.16mg/L(37 ºC)

CAS DataBase Reference: 62666-20-0

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

Toxicity: LD50 i.p. in mice: 900 mg/kg (Kaplan)

Use

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

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