PROTEIN C manufacturers and suppliers

PROTEIN C suppliers

PROTEIN C

CAS:: 60202-16-6

MF:: C33H38N4O8

MW:: 0

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Properties

Melting point:: 166-168°C

storage temp.: −20°C

solubility: H₂O: 1 mg/mL

form: lyophilized powder

color: Pale Yellow to Light Yellow

Safety Information

Hazard Codes: B

Safety Statements: 36/37

WGK Germany: 3

HS Code: 3504009000

Use

Drotrecogin alfa (activated), drotrecoginalfa (activated; Xigris), is a recombinant form of humanactivated protein C. Activated protein C exerts an antithromboticeffect by inhibiting factors Va and VIIIa. In vitro dataindicate that activated protein C has indirect profibrinolyticactivity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and to limit generation of activated thrombin-activatable fibrinolysis inhibitor. Additionally, in vitrodata indicate that activated protein C may exert an antiinflammatoryeffect by inhibiting TNF production by monocytes,by blocking leukocyte adhesion to selectins, and bylimiting the thrombin-induced inflammatory responses withinthe microvascular epithelium.Vials of drotrecogin alfa should be stored at 2°C to 8°Cwithout freezing. The reconstituted solution is stable for14 hours at 25°C.

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