R-406 suppliers
R-406
- CAS:
- 841290-80-0
- MF:
- C22H23FN6O5
- MW:
- 470.45
Suppliers by country/region
Company Type
Properties
- Melting point:
- 182-184°C
- Density
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.63±0.40(Predicted)
- color
- Off-White to Light Grey
Safety Information
- Symbol(GHS)
GHS08,GHS06
- Signal word
- Danger
- Hazard statements
- H301-H361
- Precautionary statements
- P264-P270-P301+P310-P321-P330-P405-P501-P201-P202-P281-P308+P313-P405-P501
Use
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]
125 supplier list of "R-406"
- Product Name:R-406
- Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:R-406
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:R406
- Products Intro:Package: 25 mg | CustNote: BOC Sciences also provides custom synthesis services for R406.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:R406
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:r-406
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:R406 free base
- Products Intro:Purity: 0.99 | Package: 1KG;5KG;100KG;1000KG | CustNote: 1KG,5KG,25KG,200KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:R406 free base；R406 (free base)
- Products Intro:Purity: 100.00% | Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:R-406
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
You can find R-406 suppliers,
manufacturers, and distributors from countries such as China, United States and the Canada here.
Browse to the tetrahydrofuran product information displayed by the supplier,
as well as the supplier's contact and capability information.