Tenofovir manufacturers and suppliers

Tenofovir suppliers

Properties

Melting point:: 276-280°C

alpha: D +21° (c = 1 in 0.1M HCl)

Boiling point:: 616.1±65.0 °C(Predicted)

Density: 1.79±0.1 g/cm3(Predicted)

storage temp.: -20°C

solubility: Aqueous Acid (Sparingly), DMSO (Slightly, Heated), Water (Slightly, Heated)

pka: 2.36±0.10(Predicted)

form: powder

color: white to beige

optical activity: [α]/D -20 to -26°, c = 0.5 in 1 M HCl

Water Solubility: 13.4 mg/mL (25 ºC)

Merck: 14,9146

InChI: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

InChIKey: SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES: P(CO[C@H](C)CN1C2C(N=C1)=C(N)N=CN=2)(=O)(O)O

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H332-H335

Precautionary statements: P261-P280-P305+P351+P338

RTECS: SZ6563600

HS Code: 29339900

Use

Tenofovir disoproxil is an acyclic nucleoside antivirus drug and has an inhibiting effect on HBV multi-enzyme complexes and HIV reverse transcriptase. Its active content tenofovir phosphonate directly competitively binds to natural deoxyribose substrate to inhibit the virus multi-enzyme complex and inserts itself into the DNA to end the nucleotide chain. Tenofovir disoproxil is barely absorbed by the gastrointestinal duct, so it undergoes esterification and ionization to become tenofovir ester fumarate. Tenofovir is soluble in water and can be quickly absorbed and decomposed into the active substance tenofovir, which then transforms into the active metabolite tenofovir phosphonate. As this drug is not metabolized by the CYP450 enzyme system, it has a very low chance of drug interactions caused by this enzyme.

You can find Tenofovir suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.