Tobramycin sulfate manufacturers and suppliers

Tobramycin sulfate suppliers

Properties

storage temp.: 2-8°C

solubility: Methanol (Slightly), Water (Sparingly)

form: Powder

color: White to off-white

Water Solubility: Soluble in water (50 mg/ml).

Stability:: Hygroscopic

CAS DataBase Reference: 49842-07-1

EPA Substance Registry System: Tobramycin sulfate (49842-07-1)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c

Hazard Codes: T

Risk Statements: 61-20/21/22

Safety Statements: 53-22-36/37/39-45

WGK Germany: 3

HS Code: 2941900000

Use

Introduced in 1976, tobramycin sulfate (Nebcin) is the mostactive of the chemically related aminoglycosides called nebramycinsobtained from a strain of Streptomyces tenebrarius Five members of the nebramycin complex have beenidentified chemically.Factors 4 and 4＇ are 6＂-O-carbamoylkanamycin B andkanamycin B, respectively; factors 5＇ and 6 are 6＂-O-carbamoyltobramycinand tobramycin; and factor 2 isapramycin, a tetracyclic aminoglycoside with an unusual bicycliccentral ring structure. Kanamycin B and tobramycinprobably do not occur in fermentation broths per se but areformed by hydrolysis of the 6-O＂-carbamoyl derivatives inthe isolation procedure.The most important property of tobramycin is its activityagainst most strains of P. aeruginosa, exceeding that of gentamicinby twofold to fourfold. Some gentamicin-resistantstrains of this troublesome organism are sensitive to tobramycin,but others are resistant to both antibiotics. OtherGram-negative bacilli and staphylococci are generally moresensitive to gentamicin. Tobramycin more closely resembleskanamycin B in structure (it is 3＇-deoxykanamycin B).

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