TOLBUTAMIDE manufacturers and suppliers

TOLBUTAMIDE suppliers

Properties

Melting point:: 128-130°C

Density: 1.2450

refractive index: 1.6360 (estimate)

storage temp.: Sealed in dry,Room Temperature

solubility: Soluble in chloroform.

form: Solid

pka: pKa 5.32(H2O t = 37) (Uncertain)

color: White to Off-White

Water Solubility: 0.14g/L(25 ºC)

Merck: 14,9507

BRN: 1984428

Specific Activity: 50-60 mCi/mmol

Concentration: 0.1 mCi/ml

Solvent: Ethanol

Stability:: Stable. Combustible.

CAS DataBase Reference: 64-77-7(CAS DataBase Reference)

EPA Substance Registry System: Tolbutamide (64-77-7)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H317

Precautionary statements: P261-P280g-P301+P312a-P321-P333+P313-P501a

Hazard Codes: F,Xn

Risk Statements: 20/21/22-40-43-36-11

Safety Statements: 26-36/37/39-36/37-16-24/25

WGK Germany: 2

RTECS: YS4550000

TSCA: Yes

HS Code: 29350090

Hazardous Substances Data: 64-77-7(Hazardous Substances Data)

Toxicity: LD50 oral in rat: 2490mg/kg

Use

Tolbutamide, 1-butyl-3-(p-tolylsulfonyl)urea (Orinase), occurs as a white, crystalline powderthat is insoluble in water and soluble in alcohol or aqueousalkali. It is stable in air.Tolbutamide is absorbed rapidly in responsive diabetic patients.The blood sugar level reaches a minimum after 5 to8 hours. It is oxidized rapidly in vivo to 1-butyl-3-(p-carboxyphenyl)sulfonylurea, which is inactive. The metabolite isfreely soluble at urinary pH; if the urine is strongly acidified,however, as in the use of sulfosalicylic acid as a protein precipitant,a white precipitate of the free acid may be formed.

You can find TOLBUTAMIDE suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.