3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
![3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine price.](/CAS/20180703/GIF/1013750-77-0.gif)
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- $44 - $970
- Product name: 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
- CAS: 1013750-77-0
- MF: C20H20N4O4S
- MW: 412.46
- EINECS:
- MDL Number:MFCD30719233
- Synonyms:3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine;ML-030;7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-;Inhibitor,inhibit,ML030,Phosphodiesterase (PDE),ML 030,ML-030
15 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product numberSYN5264
- Product descriptionML030
- Packaging10mg
- Price$142
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5264
- Product descriptionML030
- Packaging100mg
- Price$810
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4805
- Product descriptionML-030
- Packaging25mg
- Price$424
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15169
- Product descriptionML-030 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15169
- Product descriptionML-030 ≥98%
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15169
- Product descriptionML-030 ≥98%
- Packaging10mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15169
- Product descriptionML-030 ≥98%
- Packaging25mg
- Price$374
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-7585
- Product descriptionML-030 98.04%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7585
- Product descriptionML-030 98.04%
- Packaging10mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7585
- Product descriptionML-030 98.04%
- Packaging25mg
- Price$234
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7585
- Product descriptionML-030 98.04%
- Packaging50mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7585
- Product descriptionML-030 98.04%
- Packaging100mg
- Price$756
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number47752
- Product descriptionML-030
- Packaging25mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberM425055
- Product descriptionML-030
- Packaging100mg
- Price$970
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number456350
- Product descriptionML-030
- Packaging1mg
- Price$312
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5264 | ML030 | 10mg | $142 | 2021-12-16 | Buy |
| AK Scientific | SYN5264 | ML030 | 100mg | $810 | 2021-12-16 | Buy |
| ApexBio Technology | C4805 | ML-030 | 25mg | $424 | 2021-12-16 | Buy |
| Cayman Chemical | 15169 | ML-030 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15169 | ML-030 ≥98% | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 15169 | ML-030 ≥98% | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 15169 | ML-030 ≥98% | 25mg | $374 | 2024-03-01 | Buy |
| ChemScene | CS-7585 | ML-030 98.04% | 5mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-7585 | ML-030 98.04% | 10mg | $114 | 2021-12-16 | Buy |
| ChemScene | CS-7585 | ML-030 98.04% | 25mg | $234 | 2021-12-16 | Buy |
| ChemScene | CS-7585 | ML-030 98.04% | 50mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-7585 | ML-030 98.04% | 100mg | $756 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 47752 | ML-030 | 25mg | $800 | 2021-12-16 | Buy |
| TRC | M425055 | ML-030 | 100mg | $970 | 2021-12-16 | Buy |
| Usbiological | 456350 | ML-030 | 1mg | $312 | 2021-12-16 | Buy |
Properties
Melting point :>182°C (dec.)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
color :Off-White to Pale Yellow
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
color :Off-White to Pale Yellow
Safety Information
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Description
Type 4 cyclic nucleotide phosphodiesterases (PDE4s), which are highly expressed in neutrophils and monocytes, selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Inhibition of PDE4 activity has been examined in the context of treating asthma, chronic obstructive pulmonary disease, and as a general modulator of inflammation. ML-030 is a triazolothiadiazine that inhibits PDE4 in a cell-based cyclic nucleotide-gated cation channel biosensor assay with an EC50 value of 18.7 nM. Among the PDE4 isoforms, ML-030 displays selectivity for inhibiting PDE4A (IC50 = 6.7 nM) over PDE4B1, PDE4B2, PDE4C1, and PDE4D2 (IC50 = 48.2, 37.2, 452, and 49.2 nM, respectively).Suppliers and manufacturers
InvivoChem
TargetMol Chemicals Inc.
Nanjing Norris-Pharm Technology Co., Ltd
MedChemexpress LLC
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Changyan Chem & Tech Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Shanghai Rechem science Co., Ltd.
Beijing Solarbio Science & Tecnology Co., Ltd.
BOC Sciences