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ChemicalBook >> 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one price.
  • $110 - $744
  • Product name: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
  • CAS: 1031206-36-6
  • MF: C18H16O4
  • MW: 296.32
  • EINECS:
  • MDL Number:MFCD12912419
  • Synonyms:3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one;IMS2186;4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-, (3E)-;(E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one;(3E)-2,3-Dihydro-3-[(3-Hydroxy-4-Methoxyphenyl)Methylene]-6-Methyl-4H-1-Benzopyran-4-One
Price6 Properties Safety Information Description
6 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 5MG
  • 10MG
  • 25MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000992
  • Product descriptionIMS2186 95.00%
  • Packaging5MG
  • Price$481
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000992
  • Product descriptionIMS2186 95.00%
  • Packaging10MG
  • Price$537.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000992
  • Product descriptionIMS2186 95.00%
  • Packaging25MG
  • Price$744
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberI7160
  • Product descriptionIMS2186 ≥98% (HPLC), solid
  • Packaging5mg
  • Price$127
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberI268653
  • Product descriptionIMS2186
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number452283
  • Product descriptionIMS2186
  • Packaging5mg
  • Price$340
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation INB0000992 IMS2186 95.00% 5MG $481 2021-12-16 Buy
American Custom Chemicals Corporation INB0000992 IMS2186 95.00% 10MG $537.6 2021-12-16 Buy
American Custom Chemicals Corporation INB0000992 IMS2186 95.00% 25MG $744 2021-12-16 Buy
Sigma-Aldrich I7160 IMS2186 ≥98% (HPLC), solid 5mg $127 2024-03-01 Buy
TRC I268653 IMS2186 10mg $110 2021-12-16 Buy
Usbiological 452283 IMS2186 5mg $340 2021-12-16 Buy

Properties

Boiling point :535.7±50.0 °C(Predicted)
Density :1.286±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: >20mg/mL
form :solid
pka :9.39±0.10(Predicted)
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

An anti-proliferative and anti-angiogenic compound. IMS2186 is a novel synthetic compound developed as an anti-CNV drug. The proposed mechanism of action under investigation, is blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-. The latter contributing to anti-angiogenic and antiinflammatory effects. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 M) and cell migration, which plays a role in many biological processes: inflammation, angiogenesis, and scar formation. The physicochemical structure of IMS2186 showed also that the free drug concentration in a physiological media (e.g., vitreous or saline) is 8-10 M above the IC50 for all these activities (0.1-3.0 M). Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.

Suppliers and manufacturers

Adamas Reagent, Ltd. Shanghai EFE Biological Technology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical Bide Pharmatech Ltd. Henan Alpha Chemical Co., Ltd. Shaoguan Qicheng Biotechnology Co., Ltd TargetMol Chemicals Inc.