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ChemicalBook >> CAS DataBase List >> N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide price.
  • $44 - $12026
  • Product name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • CAS: 1072959-67-1
  • MF: C22H24N4O4
  • MW: 408.45
  • EINECS:
  • MDL Number:MFCD16619390
  • Synonyms:SR3677;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamidehydrochloride;SR 3677 hydrochloride;N-(2-(2-(diMethylaMino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxaMide;SR 3677 dihydrochloride;N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-ca;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-benzo[b][1,4]dioxin-2-carboxamide;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
Price35 Properties Safety Information Description
35 prices
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Brand
  • Adipogen Life Sciences
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
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  • 10g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1083-M010
  • Product descriptionSR 3677 ≥95%
  • Packaging10mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000777
  • Product descriptionSR 3677 95.00%
  • Packaging1MG
  • Price$228.9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000777
  • Product descriptionSR 3677 95.00%
  • Packaging10MG
  • Price$757.97
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000777
  • Product descriptionSR 3677 95.00%
  • Packaging50MG
  • Price$1478.35
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1294
  • Product descriptionSR 3677
  • Packaging10mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1294
  • Product descriptionSR 3677
  • Packaging50mg
  • Price$605
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1294
  • Product descriptionSR 3677
  • Packaging100mg
  • Price$1040
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181097
  • Product descriptionSR 3677 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181097
  • Product descriptionSR 3677 >98%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181097
  • Product descriptionSR 3677 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging2mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging5mg
  • Price$117
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging10mg
  • Price$203
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging25mg
  • Price$405
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging50mg
  • Price$704
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16708
  • Product descriptionSR 3677 ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1083-M010 SR 3677 ≥95% 10mg $227 2021-12-16 Buy
American Custom Chemicals Corporation INB0000777 SR 3677 95.00% 1MG $228.9 2021-12-16 Buy
American Custom Chemicals Corporation INB0000777 SR 3677 95.00% 10MG $757.97 2021-12-16 Buy
American Custom Chemicals Corporation INB0000777 SR 3677 95.00% 50MG $1478.35 2021-12-16 Buy
ApexBio Technology B1294 SR 3677 10mg $189 2021-12-16 Buy
ApexBio Technology B1294 SR 3677 50mg $605 2021-12-16 Buy
ApexBio Technology B1294 SR 3677 100mg $1040 2021-12-16 Buy
Biorbyt Ltd orb181097 SR 3677 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181097 SR 3677 >98% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb181097 SR 3677 >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 2mg $59 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 5mg $117 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 10mg $203 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 25mg $405 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 50mg $704 2021-12-16 Buy
Cayman Chemical 16708 SR 3677 ≥95% 1mg $44 2024-03-01 Buy
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Properties

Boiling point :646.9±55.0 °C(Predicted)
Density :1.298
storage temp. :Desiccate at RT
solubility :DMSO: soluble15mg/mL, clear
pka :11.90±0.70(Predicted)
form :powder
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK-II than ROCK-I in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively). At 3 μM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50% inhibition. SR 3677 is efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
SR-3677
$30.00 /2mg
SR-3677 CAS:1072959-67-1
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
InvivoChem
LEAPCHEM CO., LTD.
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Amadis Chemical Company Limited Shanghai Boyle Chemical Co., Ltd.