5-[(S)-(-)-2-(METHOXYMETHYL)PYRROLIDINO]SULFONYLISATIN

$117 - $517
Product name: 5-[(S)-(-)-2-(METHOXYMETHYL)PYRROLIDINO]SULFONYLISATIN
CAS: 1110670-49-9
MF: C14H16N2O5S
MW: 324.35
EINECS:
MDL Number:MFCD03456350
Synonyms:5-[(S)-(-)-2-(METHOXYMETHYL)PYRROLIDINO]SULFONYLISATIN;5-[(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINO]SULFONYLISATIN;CASPASE-3/7 INHIBITOR I;5-[2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione;5-[[2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-1H-indole-2;5-[[2-(METHOXYMETHYL)-1-PYRROLIDINYL]SULFONYL]-1H-INDOLE-2;3-DIONE;1H-Indole-2,3-dione, 5-[[2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-;abs814635

Price3 Properties Safety Information Description

3 prices

Selected condition：

Brand

AK Scientific
Cayman Chemical

Package

ManufacturerAK Scientific
Product number0313CA
Product description5-[2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
Packaging5mg
Price$517
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number14464
Product descriptionCaspase-3/7 Inhibitor I ≥98%
Packaging1mg
Price$117
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number14464
Product descriptionCaspase-3/7 Inhibitor I ≥98%
Packaging5mg
Price$377
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	0313CA	5-[2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	5mg	$517	2021-12-16	Buy
Cayman Chemical	14464	Caspase-3/7 Inhibitor I ≥98%	1mg	$117	2024-03-01	Buy
Cayman Chemical	14464	Caspase-3/7 Inhibitor I ≥98%	5mg	$377	2024-03-01	Buy

Properties

Density :1.415±0.06 g/cm3(Predicted)
solubility :DMSO: 50 mg/ml; Methanol: 10 mg/ml
form :A crystalline solid
pka :8.66±0.20(Predicted)

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 μM) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 μM) and in chondrocytes (44% inhibition at 10 μM and 98% inhibition at 50 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.

Suppliers and manufacturers

BOC Sciences Shanghai EFE Biological Technology Co., Ltd. Shanghai Amico Chemicals Co. LTD ChemeGen(Shanghai) Biotechnology Co.,Ltd. Absin Bioscience Inc. Shanghai Universal Biotech Co.,Ltd

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