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ChemicalBook >> CAS DataBase List >> Linopirdine dihydrochloride

Linopirdine dihydrochloride

Linopirdine dihydrochloride price.
  • $25 - $1340
  • Product name: Linopirdine dihydrochloride
  • CAS: 113168-57-3
  • MF: C26H22ClN3O
  • MW: 427.93
  • EINECS:
  • MDL Number:MFCD06245587
  • Synonyms:Linopirdine (hydrochloride);Linopirdine dihydrochloride (DUP-996 dihydrochloride)
Price12 Properties Safety Information Description
12 prices
Selected condition：
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Crysdot
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 50mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAmbeed
  • Product numberA463680
  • Product description1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-onedihydrochloride 98+%
  • Packaging250mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA463680
  • Product description1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-onedihydrochloride 98+%
  • Packaging1g
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA463680
  • Product description1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-onedihydrochloride 98+%
  • Packaging5g
  • Price$570
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045880
  • Product descriptionLINOPIRDINE DIHYDROCHLORIDE 95.00%
  • Packaging5MG
  • Price$516
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6916
  • Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride
  • Packaging10mg
  • Price$269
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6916
  • Product description1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride
  • Packaging50mg
  • Price$1133
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19547
  • Product descriptionLinopirdine (hydrochloride) ≥98%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19547
  • Product descriptionLinopirdine (hydrochloride) ≥98%
  • Packaging5mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19547
  • Product descriptionLinopirdine (hydrochloride) ≥98%
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11348976
  • Product descriptionLinopirdineDihydrochloride 95+%
  • Packaging1g
  • Price$446
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11348976
  • Product descriptionLinopirdineDihydrochloride 95+%
  • Packaging5g
  • Price$1340
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberL486205
  • Product descriptionLinopirdinedihydrochloride
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A463680 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-onedihydrochloride 98+% 250mg $60 2021-12-16 Buy
Ambeed A463680 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-onedihydrochloride 98+% 1g $158 2021-12-16 Buy
Ambeed A463680 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-onedihydrochloride 98+% 5g $570 2021-12-16 Buy
American Custom Chemicals Corporation API0045880 LINOPIRDINE DIHYDROCHLORIDE 95.00% 5MG $516 2021-12-16 Buy
ApexBio Technology B6916 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride 10mg $269 2021-12-16 Buy
ApexBio Technology B6916 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride 50mg $1133 2021-12-16 Buy
Cayman Chemical 19547 Linopirdine (hydrochloride) ≥98% 1mg $25 2021-12-16 Buy
Cayman Chemical 19547 Linopirdine (hydrochloride) ≥98% 5mg $99 2021-12-16 Buy
Cayman Chemical 19547 Linopirdine (hydrochloride) ≥98% 10mg $160 2021-12-16 Buy
Crysdot CD11348976 LinopirdineDihydrochloride 95+% 1g $446 2021-12-16 Buy
Crysdot CD11348976 LinopirdineDihydrochloride 95+% 5g $1340 2021-12-16 Buy
TRC L486205 Linopirdinedihydrochloride 10mg $145 2021-12-16 Buy

Properties

Melting point :257-258 °C
storage temp. :Desiccate at RT
solubility :Soluble to 100 mM in water and to 100 mM in DMSO
form :Powder

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 μM in HEK293 cells voltage clamped at -60 mV).

Suppliers and manufacturers

TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Aladdin Scientific
Amadis Chemical Company Limited Yujinpharma(Tianjin) Technology Co.,Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical MedBioPharmaceutical Technology Inc Bide Pharmatech Ltd. TargetMol Chemicals Inc.