N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
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- $32 - $4137
- Product name: N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
- CAS: 1191911-26-8
- MF: C22H25FN6O4S
- MW: 488.54
- EINECS:
- MDL Number:MFCD28160475
- Synonyms:CZC-25146;N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide;N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide;N-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamide;CZC-25146 freebase;CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide;Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-;CHEMBL2397014
26 prices
Selected condition：
Brand
- Ambeed
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 10
- 25mg
- 50mg
- 100mg
- 250mg
- 50
- 1g
- 10mM(in 1mL DMSO)
- 1000mg
- ManufacturerAmbeed
- Product numberA269266
- Product descriptionCZC-25146 98+%
- Packaging10mg
- Price$227
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269266
- Product descriptionCZC-25146 98+%
- Packaging100mg
- Price$1103
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269266
- Product descriptionCZC-25146 98+%
- Packaging1g
- Price$4137
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4635
- Product descriptionCZC-25146
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4635
- Product descriptionCZC-25146
- Packaging10mM(in 1mL DMSO)
- Price$174
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4635
- Product descriptionCZC-25146
- Packaging100mg
- Price$1197
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180975
- Product descriptionCZC-25146 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180975
- Product descriptionCZC-25146 >98%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180975
- Product descriptionCZC-25146 >98%
- Packaging1000mg
- Price$2839
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC103257
- Product descriptionCZC 25146
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC103257
- Product descriptionCZC 25146
- Packaging50mg
- Price$647.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22931
- Product descriptionCZC-25146 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22931
- Product descriptionCZC-25146 ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22931
- Product descriptionCZC-25146 ≥98%
- Packaging10mg
- Price$199
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22931
- Product descriptionCZC-25146 ≥98%
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM163879
- Product descriptionN-(2-((5-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide 98%
- Packaging100mg
- Price$825
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A269266 | CZC-25146 98+% | 10mg | $227 | 2021-12-16 | Buy |
| Ambeed | A269266 | CZC-25146 98+% | 100mg | $1103 | 2021-12-16 | Buy |
| Ambeed | A269266 | CZC-25146 98+% | 1g | $4137 | 2021-12-16 | Buy |
| ApexBio Technology | B4635 | CZC-25146 | 10mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B4635 | CZC-25146 | 10mM(in 1mL DMSO) | $174 | 2021-12-16 | Buy |
| ApexBio Technology | B4635 | CZC-25146 | 100mg | $1197 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180975 | CZC-25146 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180975 | CZC-25146 >98% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180975 | CZC-25146 >98% | 1000mg | $2839 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC103257 | CZC 25146 | 10mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC103257 | CZC 25146 | 50mg | $647.5 | 2021-12-16 | Buy |
| Cayman Chemical | 22931 | CZC-25146 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22931 | CZC-25146 ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 22931 | CZC-25146 ≥98% | 10mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 22931 | CZC-25146 ≥98% | 25mg | $456 | 2024-03-01 | Buy |
| Chemenu | CM163879 | N-(2-((5-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide 98% | 100mg | $825 | 2021-12-16 | Buy |
Properties
Boiling point :697.4±65.0 °C(Predicted)
Density :1.436±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :8.48±0.10(Predicted)
color :Pale purple to purple
Density :1.436±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :8.48±0.10(Predicted)
color :Pale purple to purple
Safety Information
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Description
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase). It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.Suppliers and manufacturers
career henan chemical co
ATK CHEMICAL COMPANY LIMITED
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
$1.00 /1g
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide CAS:1191911-26-8
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide CAS:1191911-26-8
