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ChemicalBook >> CAS DataBase List >> 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide price.
  • $65 - $404
  • Product name: 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
  • CAS: 1255516-86-9
  • MF: C21H18N2O3
  • MW: 346.38
  • EINECS:
  • MDL Number:MFCD21363377
  • Synonyms:1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide;1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide;MS-1020;1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide;2-Naphthalenecarboxamide, 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-;MS-1020 >=98% (HPLC)
Price6 Properties Safety Information Description
6 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
  • Usbiological
Package
  • 1mg
  • 5mg
  • 25mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3501-M001
  • Product descriptionMS-1020 ≥95%(NMR)
  • Packaging1mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number6700DW
  • Product description1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide
  • Packaging1mg
  • Price$201
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14273
  • Product descriptionMS-1020 ≥95%
  • Packaging1mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0204
  • Product descriptionMS-1020 ≥98% (HPLC)
  • Packaging5mg
  • Price$113
  • Updated2022-05-15
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0204
  • Product descriptionMS-1020 ≥98% (HPLC)
  • Packaging25mg
  • Price$404
  • Updated2024-03-01
  • Buy
  • ManufacturerUsbiological
  • Product number045047
  • Product descriptionMS-1020
  • Packaging1mg
  • Price$303
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3501-M001 MS-1020 ≥95%(NMR) 1mg $65 2021-12-16 Buy
AK Scientific 6700DW 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide 1mg $201 2021-12-16 Buy
Cayman Chemical 14273 MS-1020 ≥95% 1mg $93 2024-03-01 Buy
Sigma-Aldrich SML0204 MS-1020 ≥98% (HPLC) 5mg $113 2022-05-15 Buy
Sigma-Aldrich SML0204 MS-1020 ≥98% (HPLC) 25mg $404 2024-03-01 Buy
Usbiological 045047 MS-1020 1mg $303 2021-12-16 Buy

Properties

storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL at 60°C
form :powder
color :white to tan

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM. It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Hangzhou MolCore BioPharmatech Co.,Ltd.
Aladdin Scientific Shanghai EFE Biological Technology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical TargetMol Chemicals Inc.