(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
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- $106 - $723
- Product name: (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
- CAS: 136696-10-1
- MF: C20H30O4
- MW: 334.45
- EINECS:
- MDL Number:MFCD00065854
- Synonyms:(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid;12-Keto-leukotriene B4;12-oxoleukotriene B4;12-Oxo-ltb4;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))-;12-dehydro-leukotriene B4;SJVWVCVZWMJXOK-NOJHDUNKSA-N;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)-
5 prices
Selected condition：
Brand
- Cayman Chemical
- TRC
Package
- 10μg
- 25μg
- 50μg
- 100μg
- 50μL
- ManufacturerCayman Chemical
- Product number20140
- Product description12-oxo Leukotriene B4
- Packaging10μg
- Price$106
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20140
- Product description12-oxo Leukotriene B4 ≥90%
- Packaging25μg
- Price$222
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20140
- Product description12-oxo Leukotriene B4 ≥90%
- Packaging50μg
- Price$414
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20140
- Product description12-oxo Leukotriene B4 ≥90%
- Packaging100μg
- Price$723
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberL330410
- Product description12-OxoleukotrieneB4inacetonitrile
- Packaging50μL
- Price$380
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 20140 | 12-oxo Leukotriene B4 | 10μg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 20140 | 12-oxo Leukotriene B4 ≥90% | 25μg | $222 | 2024-03-01 | Buy |
| Cayman Chemical | 20140 | 12-oxo Leukotriene B4 ≥90% | 50μg | $414 | 2024-03-01 | Buy |
| Cayman Chemical | 20140 | 12-oxo Leukotriene B4 ≥90% | 100μg | $723 | 2024-03-01 | Buy |
| TRC | L330410 | 12-OxoleukotrieneB4inacetonitrile | 50μL | $380 | 2021-12-16 | Buy |
Properties
Boiling point :524.2±50.0 °C(Predicted)
Density :1.036±0.06 g/cm3(Predicted)
storage temp. :Store at -80°C,protect from light
solubility :DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): > 1 mg/ml
pka :4.66±0.10(Predicted)
Density :1.036±0.06 g/cm3(Predicted)
storage temp. :Store at -80°C,protect from light
solubility :DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): > 1 mg/ml
pka :4.66±0.10(Predicted)
Safety Information
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| Signal word: | Danger | |||||||
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Description
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.More related product prices
