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ChemicalBook >> CAS DataBase List >> 14,15-LEUKOTRIENE D4

14,15-LEUKOTRIENE D4

14,15-LEUKOTRIENE D4 price.
  • $127 - $447
  • Product name: 14,15-LEUKOTRIENE D4
  • CAS: 75290-64-1
  • MF: C25H40N2O6S
  • MW: 496.66
  • EINECS:
  • MDL Number:MFCD00211502
  • Synonyms:14,15-LEUKOTRIENE D4;Eoxin D4;Glycine, S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
Price4 Properties Safety Information Description
4 prices
Selected condition：
Brand
  • Cayman Chemical
  • TRC
Package
  • 25μg
  • 50μg
  • 100μg
  • 50g
  • ManufacturerCayman Chemical
  • Product number10011361
  • Product description14,15-Leukotriene D4 ≥97%
  • Packaging25μg
  • Price$127
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10011361
  • Product description14,15-Leukotriene D4 ≥97%
  • Packaging50μg
  • Price$236
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10011361
  • Product description14,15-Leukotriene D4 ≥97%
  • Packaging100μg
  • Price$447
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberE561500
  • Product descriptionEoxinD4
  • Packaging50g
  • Price$195
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10011361 14,15-Leukotriene D4 ≥97% 25μg $127 2024-03-01 Buy
Cayman Chemical 10011361 14,15-Leukotriene D4 ≥97% 50μg $236 2024-03-01 Buy
Cayman Chemical 10011361 14,15-Leukotriene D4 ≥97% 100μg $447 2024-03-01 Buy
TRC E561500 EoxinD4 50g $195 2021-12-16 Buy

Properties

Boiling point :786.4±60.0 °C(Predicted)
Density :1.162±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): >100 μg/ml
pka :3.03±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.

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