2-[(1-Methylpropyl)dithio]-1H-imidazole
![2-[(1-Methylpropyl)dithio]-1H-imidazole price.](/CAS/GIF/141400-58-0.gif)
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- $22 - $1965
- Product name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
- CAS: 141400-58-0
- MF: C7H12N2S2
- MW: 188.31
- EINECS:
- MDL Number:MFCD18086851
- Synonyms:2-[(1-Methylpropyl)dithio]-1H-imidazole;PX 12;2-(sec-Butyldisulfanyl)-1H-iMidazole;CS-2384;IV-2);PX-12 (PX12;1H-Imidazole, 2-[(1-methylpropyl)dithio]-;IV 2,inhibit,PX 12,PX-12,Inhibitor,IV2
39 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- 25mg
- 50
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3739-M005
- Product descriptionPX 12 ≥98%(HPLC)
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3122AH
- Product description2-(Sec-butyldisulfanyl)-1H-imidazole
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3122AH
- Product description2-(Sec-butyldisulfanyl)-1H-imidazole
- Packaging100mg
- Price$784
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging1mg
- Price$22
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging5mg
- Price$48
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging10mg
- Price$62
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging25mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging50mg
- Price$239
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging100mg
- Price$374
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging250mg
- Price$578
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112791
- Product descriptionPX 12 98+%
- Packaging1g
- Price$1965
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000637
- Product descriptionPX 12 95.00%
- Packaging5MG
- Price$404.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000637
- Product descriptionPX 12 95.00%
- Packaging1G
- Price$1340
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4509
- Product descriptionPX 12
- Packaging10mM(in 1mL DMSO)
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4509
- Product descriptionPX 12
- Packaging10mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4509
- Product descriptionPX 12
- Packaging50mg
- Price$338
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3739-M005 | PX 12 ≥98%(HPLC) | 5mg | $60 | 2021-12-16 | Buy |
| AK Scientific | 3122AH | 2-(Sec-butyldisulfanyl)-1H-imidazole | 25mg | $250 | 2021-12-16 | Buy |
| AK Scientific | 3122AH | 2-(Sec-butyldisulfanyl)-1H-imidazole | 100mg | $784 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 1mg | $22 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 5mg | $48 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 10mg | $62 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 25mg | $126 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 50mg | $239 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 100mg | $374 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 250mg | $578 | 2021-12-16 | Buy |
| Ambeed | A112791 | PX 12 98+% | 1g | $1965 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000637 | PX 12 95.00% | 5MG | $404.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000637 | PX 12 95.00% | 1G | $1340 | 2021-12-16 | Buy |
| ApexBio Technology | A4509 | PX 12 | 10mM(in 1mL DMSO) | $63 | 2021-12-16 | Buy |
| ApexBio Technology | A4509 | PX 12 | 10mg | $88 | 2021-12-16 | Buy |
| ApexBio Technology | A4509 | PX 12 | 50mg | $338 | 2021-12-16 | Buy |
Properties
Boiling point :330.0±25.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >25mg/mL
pka :11.88±0.10(Predicted)
form :powder
color :off-white to tan
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >25mg/mL
pka :11.88±0.10(Predicted)
form :powder
color :off-white to tan
Safety Information
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Description
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA. Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts. PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.More related product prices
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