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ChemicalBook >> CAS DataBase List >> 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine price.
  • $35 - $2300
  • Product name: 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
  • CAS: 1527503-11-2
  • MF: C19H27N3O2
  • MW: 329.44
  • EINECS:808-907-0
  • MDL Number:MFCD28133403
  • Synonyms:5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine;A-366;A-336;CS-2077;A-366; A366;A 366;5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine;Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-;11,selective,cells,peptide-competitive,epigenetics,Inhibitor,interaction,inhibit,H3K4me3,Epigenetic Reader Domain,leukemia,Histone Methyltransferase,methyltransferase
Price23 Properties Safety Information Description
23 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
Package
  • 10
  • 10mg
  • 50
  • 1mg
  • 5mg
  • 25MG
  • 50mg
  • 250mg
  • 1g
  • 100mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number9081DX
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine
  • Packaging5mg
  • Price$191
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120345
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+%
  • Packaging1mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120345
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+%
  • Packaging50mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120345
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+%
  • Packaging250mg
  • Price$601
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4947
  • Product descriptionA366
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4947
  • Product descriptionA366
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4947
  • Product descriptionA366
  • Packaging50mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16081
  • Product descriptionA-366 ≥98%
  • Packaging5mg
  • Price$85
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16081
  • Product descriptionA-366 ≥98%
  • Packaging10mg
  • Price$158
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16081
  • Product descriptionA-366 ≥98%
  • Packaging50mg
  • Price$661
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging10mg
  • Price$102
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging50mg
  • Price$374
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging100mg
  • Price$636
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging250mg
  • Price$1029
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4644
  • Product descriptionA-366 98.02%
  • Packaging5mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4644
  • Product descriptionA-366 98.02%
  • Packaging10mg
  • Price$132
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9081DX 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 5mg $191 2021-12-16 Buy
Ambeed A120345 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+% 1mg $35 2021-12-16 Buy
Ambeed A120345 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+% 50mg $218 2021-12-16 Buy
Ambeed A120345 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+% 250mg $601 2021-12-16 Buy
ApexBio Technology B4947 A366 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B4947 A366 10mg $100 2021-12-16 Buy
ApexBio Technology B4947 A366 50mg $400 2021-12-16 Buy
Cayman Chemical 16081 A-366 ≥98% 5mg $85 2024-03-01 Buy
Cayman Chemical 16081 A-366 ≥98% 10mg $158 2024-03-01 Buy
Cayman Chemical 16081 A-366 ≥98% 50mg $661 2024-03-01 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 10mg $102 2021-12-16 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 50mg $374 2021-12-16 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 100mg $636 2021-12-16 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 250mg $1029 2021-12-16 Buy
ChemScene CS-4644 A-366 98.02% 5mg $78 2021-12-16 Buy
ChemScene CS-4644 A-366 98.02% 10mg $132 2021-12-16 Buy
Next Last

Properties

Boiling point :533.6±60.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO : 50 mg/mL (151.77 mM; Need ultrasonic)
pka :10.18±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment

Description

A-366 is a potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM). It displays greater than 1,000-fold selectivity over 21 other methyltransferases. A-366 significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing total histone 3, H3K27Me3, or H3K36Me2. It also blocks the interaction of the methyl lysine reader protein Spindlin1 with H3K4me3 by binding with a Spindlin1 Tudor domain (Kd = 111 nM). See the Structural Genomics Consortium (SGC) website for more information.

Suppliers and manufacturers

TargetMol Chemicals Inc.
A-366
$30.00 /1mg
A-366 CAS:1527503-11-2
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited