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ChemicalBook >> CAS DataBase List >> 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine price.
  • $35 - $2300
  • Product name: 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
  • CAS: 1527503-11-2
  • MF: C19H27N3O2
  • MW: 329.44
  • EINECS:808-907-0
  • MDL Number:MFCD28133403
  • Synonyms:5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine;A-366;A-336;CS-2077;A-366; A366;A 366;5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine;Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-;11,selective,cells,peptide-competitive,epigenetics,Inhibitor,interaction,inhibit,H3K4me3,Epigenetic Reader Domain,leukemia,Histone Methyltransferase,methyltransferase
Price23 Properties Safety Information Description
23 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
Package
  • 10
  • 10mg
  • 50
  • 1mg
  • 5mg
  • 25MG
  • 50mg
  • 250mg
  • 1g
  • 100mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number9081DX
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine
  • Packaging5mg
  • Price$191
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120345
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+%
  • Packaging1mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120345
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+%
  • Packaging50mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120345
  • Product description5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+%
  • Packaging250mg
  • Price$601
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4947
  • Product descriptionA366
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4947
  • Product descriptionA366
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4947
  • Product descriptionA366
  • Packaging50mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16081
  • Product descriptionA-366 ≥98%
  • Packaging5mg
  • Price$85
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16081
  • Product descriptionA-366 ≥98%
  • Packaging10mg
  • Price$158
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16081
  • Product descriptionA-366 ≥98%
  • Packaging50mg
  • Price$661
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging10mg
  • Price$102
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging50mg
  • Price$374
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging100mg
  • Price$636
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM243695
  • Product description5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98%
  • Packaging250mg
  • Price$1029
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4644
  • Product descriptionA-366 98.02%
  • Packaging5mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4644
  • Product descriptionA-366 98.02%
  • Packaging10mg
  • Price$132
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9081DX 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 5mg $191 2021-12-16 Buy
Ambeed A120345 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+% 1mg $35 2021-12-16 Buy
Ambeed A120345 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+% 50mg $218 2021-12-16 Buy
Ambeed A120345 5'-Methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine 98+% 250mg $601 2021-12-16 Buy
ApexBio Technology B4947 A366 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B4947 A366 10mg $100 2021-12-16 Buy
ApexBio Technology B4947 A366 50mg $400 2021-12-16 Buy
Cayman Chemical 16081 A-366 ≥98% 5mg $85 2024-03-01 Buy
Cayman Chemical 16081 A-366 ≥98% 10mg $158 2024-03-01 Buy
Cayman Chemical 16081 A-366 ≥98% 50mg $661 2024-03-01 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 10mg $102 2021-12-16 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 50mg $374 2021-12-16 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 100mg $636 2021-12-16 Buy
Chemenu CM243695 5''-Methoxy-6''-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3''-indol]-2''-amine 98% 250mg $1029 2021-12-16 Buy
ChemScene CS-4644 A-366 98.02% 5mg $78 2021-12-16 Buy
ChemScene CS-4644 A-366 98.02% 10mg $132 2021-12-16 Buy
Next Last

Properties

Boiling point :533.6±60.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO : 50 mg/mL (151.77 mM; Need ultrasonic)
pka :10.18±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment

Description

A-366 is a potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM). It displays greater than 1,000-fold selectivity over 21 other methyltransferases. A-366 significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing total histone 3, H3K27Me3, or H3K36Me2. It also blocks the interaction of the methyl lysine reader protein Spindlin1 with H3K4me3 by binding with a Spindlin1 Tudor domain (Kd = 111 nM). See the Structural Genomics Consortium (SGC) website for more information.

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited DKMbiochem.Co. Ltd