BAY 61-3606 (hydrochloride)
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- $57 - $1100
- Product name: BAY 61-3606 (hydrochloride)
- CAS: 1615197-10-8
- MF: C20H19ClN6O3
- MW: 426.86
- EINECS:
- MDL Number:
- Synonyms:BAY 61-3606 (hydrochloride);BAY 61-3606 2HCl
8 prices
Selected condition：
Brand
- Cayman Chemical
- DC Chemicals
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 100mg
- 250mg
- ManufacturerCayman Chemical
- Product number11423
- Product descriptionBAY 61-3606 (hydrochloride) ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11423
- Product descriptionBAY 61-3606 (hydrochloride) ≥98%
- Packaging5mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11423
- Product descriptionBAY 61-3606 (hydrochloride) ≥98%
- Packaging10mg
- Price$310
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC26066
- Product descriptionBAY61-3606hydrochloride >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC26066
- Product descriptionBAY61-3606hydrochloride >98%
- Packaging250mg
- Price$1100
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberB119075
- Product descriptionBAY61-3606Hydrochloride
- Packaging10mg
- Price$310
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberB119075
- Product descriptionBAY61-3606Hydrochloride
- Packaging25mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberB0184
- Product descriptionBay 61-3606 Hydrochloride
- Packaging1mg
- Price$319
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 11423 | BAY 61-3606 (hydrochloride) ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 11423 | BAY 61-3606 (hydrochloride) ≥98% | 5mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 11423 | BAY 61-3606 (hydrochloride) ≥98% | 10mg | $310 | 2024-03-01 | Buy |
| DC Chemicals | DC26066 | BAY61-3606hydrochloride >98% | 100mg | $600 | 2021-12-16 | Buy |
| DC Chemicals | DC26066 | BAY61-3606hydrochloride >98% | 250mg | $1100 | 2021-12-16 | Buy |
| TRC | B119075 | BAY61-3606Hydrochloride | 10mg | $310 | 2021-12-16 | Buy |
| TRC | B119075 | BAY61-3606Hydrochloride | 25mg | $650 | 2021-12-16 | Buy |
| Usbiological | B0184 | Bay 61-3606 Hydrochloride | 1mg | $319 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF:1.0(Max Conc. mg/mL);2.34(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);70.28(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:30):0.03(Max Conc. mg/mL);0.07(Max Conc. mM)
Ethanol:0.1(Max Conc. mg/mL);0.23(Max Conc. mM) form :A crystalline solid
solubility :DMF:1.0(Max Conc. mg/mL);2.34(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);70.28(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:30):0.03(Max Conc. mg/mL);0.07(Max Conc. mM)
Ethanol:0.1(Max Conc. mg/mL);0.23(Max Conc. mM) form :A crystalline solid
Safety Information
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Description
BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. At 3 mg/kg, oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.Suppliers and manufacturers
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