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ChemicalBook >> CAS DataBase List >> 18β-Glycyrrhetinic Acid

18β-Glycyrrhetinic Acid

18β-Glycyrrhetinic Acid price.
  • $19.8 - $3176.25
  • Product name: 18β-Glycyrrhetinic Acid
  • CAS: 471-53-4
  • MF: C30H46O4
  • MW: 470.69
  • EINECS:207-444-6
  • MDL Number:MFCD00003706
  • Synonyms:Enoxolone, 3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid;Aloe Vera, Freeze Dried Powder;18-β-Glycyrrhetinic acid, 98+%;18-beta-glycyrrheticacid ;Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3b,20b)-;(20S)-3β-Hydroxy-11-oxo-5α-olean-12-en-29-oic acid;GLYCYRRHETINIC ACID, 18B-(P);Glycyrrhetinic acid ,98%
43 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • 10mg
  • e0180500
  • 5MG
  • 20mg
  • 25mg
  • 1g
  • 1000mg
  • 5g
  • 10G
  • 25g
  • 50g
  • 100g
  • 250g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberC425
  • Product descriptionEnoxolone
  • Packaging5g
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10770
  • Product descriptionEnoxolone
  • Packaging25mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10770
  • Product descriptionEnoxolone
  • Packaging1g
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0007789
  • Product description(2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-HYDROXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-2-CARBOXYLIC ACID 95.00%
  • Packaging1G
  • Price$131.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0005604
  • Product description18-BETA GLYCYRRHETINIC ACID 95.00%
  • Packaging5MG
  • Price$458.56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002854
  • Product descriptionGLYCYRRHETINIC ACID 95.00%
  • Packaging1G
  • Price$704.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002854
  • Product descriptionGLYCYRRHETINIC ACID 95.00%
  • Packaging10G
  • Price$2055.9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0007789
  • Product description(2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-HYDROXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-2-CARBOXYLIC ACID 95.00%
  • Packaging5G
  • Price$2252.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0007789
  • Product description(2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-HYDROXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-2-CARBOXYLIC ACID 95.00%
  • Packaging10G
  • Price$3176.25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5986
  • Product descriptionEnoxolone
  • Packaging1g
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5986
  • Product descriptionEnoxolone
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5986
  • Product descriptionEnoxolone
  • Packaging5g
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99152
  • Product descriptionGlycyrrhetinicacid ≥98%
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY075768
  • Product description(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-Hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylicAcid ≥98%
  • Packaging10mg
  • Price$40.91
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1106
  • Product description18-Beta-Glycyrrhetinic Acid
  • Packaging1g
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb593978
  • Product descriptionGlycyrrhetinic acid
  • Packaging20mg
  • Price$153
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific C425 Enoxolone 5g $27 2021-12-16 Buy
AK Scientific J10770 Enoxolone 25mg $39 2021-12-16 Buy
AK Scientific J10770 Enoxolone 1g $149 2021-12-16 Buy
American Custom Chemicals Corporation CCH0007789 (2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-HYDROXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-2-CARBOXYLIC ACID 95.00% 1G $131.25 2021-12-16 Buy
American Custom Chemicals Corporation PXT0005604 18-BETA GLYCYRRHETINIC ACID 95.00% 5MG $458.56 2021-12-16 Buy
American Custom Chemicals Corporation API0002854 GLYCYRRHETINIC ACID 95.00% 1G $704.55 2021-12-16 Buy
American Custom Chemicals Corporation API0002854 GLYCYRRHETINIC ACID 95.00% 10G $2055.9 2021-12-16 Buy
American Custom Chemicals Corporation CCH0007789 (2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-HYDROXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-2-CARBOXYLIC ACID 95.00% 5G $2252.25 2021-12-16 Buy
American Custom Chemicals Corporation CCH0007789 (2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-HYDROXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-2-CARBOXYLIC ACID 95.00% 10G $3176.25 2021-12-16 Buy
ApexBio Technology B5986 Enoxolone 1g $50 2021-12-16 Buy
ApexBio Technology B5986 Enoxolone 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B5986 Enoxolone 5g $85 2021-12-16 Buy
Arctom CFN99152 Glycyrrhetinicacid ≥98% 20mg $30 2021-12-16 Buy
Arctom SY075768 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-Hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylicAcid ≥98% 10mg $40.91 2021-12-16 Buy
AvaChem 1106 18-Beta-Glycyrrhetinic Acid 1g $59 2021-12-16 Buy
Biorbyt Ltd orb593978 Glycyrrhetinic acid 20mg $153 2021-12-16 Buy

Properties

Melting point :292-295 °C(lit.)
alpha :165 º (c=1, CHCl3,on dry ba)
Boiling point :492.11°C (rough estimate)
Density :0.9967 (rough estimate)
vapor pressure :10-220Pa at 20-50℃
refractive index :162 ° (C=1, MeOH)
storage temp. :2-8°C
solubility :Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.
pka :pKa 5.56±0.1 (Uncertain)
form :Crystalline Powder
color :White to off-white
optical activity :[α]22/D +170.0°, c = 1 in chloroform
Water Solubility :SOLUBLE IN ACETIC ACID
Merck :14,3590
BRN :2229654
LogP :4.5 at 20℃
CAS DataBase Reference :471-53-4(CAS DataBase Reference)
EPA Substance Registry System :Enoxolone (471-53-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. Both β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit antiulcerative, anti-inflammatory, and immunomodulatory properties. β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM). At 100 mg/kg/day, β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats. β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively. At 100-200 μM, β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.

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