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ChemicalBook >> CAS DataBase List >> 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline dihydrochloride

8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline dihydrochloride

8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline dihydrochloride price.
9 prices
Selected condition:
Brand
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • ManufacturerBiosynth Carbosynth
  • Product numberFD146326
  • Product descriptionNVP BSK 805 dihydrochloride
  • Packaging10mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD146326
  • Product descriptionNVP BSK 805 dihydrochloride
  • Packaging50mg
  • Price$647.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16714
  • Product descriptionNVP-BSK805 (hydrochloride)
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16714
  • Product descriptionNVP-BSK805 (hydrochloride)
  • Packaging5mg
  • Price$286
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16714
  • Product descriptionNVP-BSK805 (hydrochloride)
  • Packaging10mg
  • Price$401
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2287
  • Product descriptionNVP-BSK805(dihydrochloride) 99.36%
  • Packaging5mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2287
  • Product descriptionNVP-BSK805(dihydrochloride) 99.36%
  • Packaging10mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2287
  • Product descriptionNVP-BSK805(dihydrochloride) 99.36%
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2287
  • Product descriptionNVP-BSK805(dihydrochloride) 99.36%
  • Packaging100mg
  • Price$1140
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Biosynth Carbosynth FD146326 NVP BSK 805 dihydrochloride 10mg $185 2021-12-16 Buy
Biosynth Carbosynth FD146326 NVP BSK 805 dihydrochloride 50mg $647.5 2021-12-16 Buy
Cayman Chemical 16714 NVP-BSK805 (hydrochloride) 1mg $68 2024-03-01 Buy
Cayman Chemical 16714 NVP-BSK805 (hydrochloride) 5mg $286 2024-03-01 Buy
Cayman Chemical 16714 NVP-BSK805 (hydrochloride) 10mg $401 2024-03-01 Buy
ChemScene CS-2287 NVP-BSK805(dihydrochloride) 99.36% 5mg $168 2021-12-16 Buy
ChemScene CS-2287 NVP-BSK805(dihydrochloride) 99.36% 10mg $252 2021-12-16 Buy
ChemScene CS-2287 NVP-BSK805(dihydrochloride) 99.36% 50mg $720 2021-12-16 Buy
ChemScene CS-2287 NVP-BSK805(dihydrochloride) 99.36% 100mg $1140 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
color :Light yellow to yellow

Safety Information

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Description

Janus kinases (JAKs) are non-receptor tyrosine kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (STAT) family. A point mutation of JAK2, V617F, activates signaling through STAT5 and drives certain forms of cancer. NVP-BSK805 is a potent inhibitor of JAK2 that also inhibits the JAK2V617F mutant enzyme (IC50s for both enzymes ~ 0.5 nM). It displays at least 20-fold selectivity against other JAK enzymes and a panel of serine/threonine and tyrosine kinases. This ATP-competitive inhibitor is orally bioavailable and has a long half-life in vivo, suppressing leukemic cell spreading and splenomegaly in JAK2V617F cell-driven disease in mice. NVP-BSK805 suppresses recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats. NVP-BSK805 can be used to study the molecular mechanisms involved in JAK2V617F signaling in cells.