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ChemicalBook >> CAS DataBase List >> 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea

1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea

1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea price.
  • $33 - $3180
  • Product name: 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
  • CAS: 1997387-43-5
  • MF: C19H27N3O2S
  • MW: 361.5
  • EINECS:-0
  • MDL Number:MFCD30802176
  • Synonyms:1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea;PZM-21;PZM 21; PZM-21;1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea;Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-;Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21
18 prices
Selected condition:
Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Tocris
  • TRC
Package
  • 5mg
  • 50
  • 1mg
  • 10
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number8566EG
  • Product descriptionCID121596705
  • Packaging10mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBP167100
  • Product descriptionPZM 21
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBP167100
  • Product descriptionPZM 21
  • Packaging50mg
  • Price$507.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20576
  • Product descriptionPZM21
  • Packaging10mg
  • Price$164
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20576
  • Product descriptionPZM21
  • Packaging1mg
  • Price$33
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20576
  • Product descriptionPZM21
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20576
  • Product descriptionPZM21
  • Packaging25mg
  • Price$245
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6424
  • Product descriptionPZM21 99.84%
  • Packaging1mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6424
  • Product descriptionPZM21 99.84%
  • Packaging5mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6424
  • Product descriptionPZM21 99.84%
  • Packaging10mg
  • Price$780
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6424
  • Product descriptionPZM21 99.84%
  • Packaging50mg
  • Price$2340
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6424
  • Product descriptionPZM21 99.84%
  • Packaging100mg
  • Price$3180
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10290
  • Product descriptionPZM21 >98%
  • Packaging250mg
  • Price$1400
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10290
  • Product descriptionPZM21 >98%
  • Packaging1g
  • Price$2800
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number7218
  • Product descriptionPZM21 ≥98%(HPLC)
  • Packaging50
  • Price$839
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number7218
  • Product descriptionPZM21 ≥98%(HPLC)
  • Packaging10
  • Price$199
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8566EG CID121596705 10mg $245 2021-12-16 Buy
Biosynth Carbosynth BP167100 PZM 21 10mg $145 2021-12-16 Buy
Biosynth Carbosynth BP167100 PZM 21 50mg $507.5 2021-12-16 Buy
Cayman Chemical 20576 PZM21 10mg $164 2024-03-01 Buy
Cayman Chemical 20576 PZM21 1mg $33 2024-03-01 Buy
Cayman Chemical 20576 PZM21 5mg $116 2024-03-01 Buy
Cayman Chemical 20576 PZM21 25mg $245 2024-03-01 Buy
ChemScene CS-6424 PZM21 99.84% 1mg $180 2021-12-16 Buy
ChemScene CS-6424 PZM21 99.84% 5mg $540 2021-12-16 Buy
ChemScene CS-6424 PZM21 99.84% 10mg $780 2021-12-16 Buy
ChemScene CS-6424 PZM21 99.84% 50mg $2340 2021-12-16 Buy
ChemScene CS-6424 PZM21 99.84% 100mg $3180 2021-12-16 Buy
DC Chemicals DC10290 PZM21 >98% 250mg $1400 2021-12-16 Buy
DC Chemicals DC10290 PZM21 >98% 1g $2800 2021-12-16 Buy
Tocris 7218 PZM21 ≥98%(HPLC) 50 $839 2021-12-16 Buy
Tocris 7218 PZM21 ≥98%(HPLC) 10 $199 2021-12-16 Buy

Properties

Boiling point :583.8±50.0 °C(Predicted)
Density :1.169±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);276.63(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);27.7(Max Conc. mM) form :A crystalline solid
pka :10.06±0.15(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses.