(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
![(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol price.](/CAS/20180601/GIF/2040291-27-6.gif)
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- $32 - $2400
- Product name: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
- CAS: 2040291-27-6
- MF: C17H18N4O4
- MW: 342.35
- EINECS:
- MDL Number:MFCD31657362
- Synonyms:(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol;LLY-283;LM-5179;LLY-283 (LLY283);7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-;LLY-283 >=98% (HPLC);7-[(5R)-5-CPhenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
12 prices
Selected condition：
Brand
- AK Scientific
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3430EH
- Product descriptionCID122669401
- Packaging25mg
- Price$606
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBL166665
- Product descriptionLLY 283
- Packaging100mg
- Price$1950
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging100mg
- Price$940
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21240
- Product descriptionLLY-283 >98%
- Packaging250mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21240
- Product descriptionLLY-283 >98%
- Packaging1g
- Price$2400
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3430EH | CID122669401 | 25mg | $606 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BL166665 | LLY 283 | 100mg | $1950 | 2021-12-16 | Buy |
| Cayman Chemical | 21596 | LLY-283 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21596 | LLY-283 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 21596 | LLY-283 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 21596 | LLY-283 | 25mg | $456 | 2024-03-01 | Buy |
| ChemScene | CS-0030144 | LLY-283 99.04% | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0030144 | LLY-283 99.04% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0030144 | LLY-283 99.04% | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-0030144 | LLY-283 99.04% | 100mg | $940 | 2021-12-16 | Buy |
| DC Chemicals | DC21240 | LLY-283 >98% | 250mg | $1200 | 2021-12-16 | Buy |
| DC Chemicals | DC21240 | LLY-283 >98% | 1g | $2400 | 2021-12-16 | Buy |
Properties
Boiling point :688.9±55.0 °C(Predicted)
Density :1?+-.0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 60 mg/ml; Ethanol: 60 mg/ml
form :A crystalline solid
pka :12.46±0.70(Predicted)
color :White to off-white
Density :1?+-.0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 60 mg/ml; Ethanol: 60 mg/ml
form :A crystalline solid
pka :12.46±0.70(Predicted)
color :White to off-white
Safety Information
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Description
LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 μM. It reduces symmetric demethylation of SmBB'' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric, hematological, lung, skin, and ovarian cancer cell lines (IC50s = 3-30 nM). LLY-283 (20 mg/kg) inhibits tumor growth in an A375 mouse xenograft model. It also disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells and increases survival in an orthotopic patient-derived xenograft (PDX) mouse model. See the Structural Genomics Consortium (SGC) website for more information.Suppliers and manufacturers
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
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InvivoChem
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Amadis Chemical Company Limited
BOC Sciences
ShangHai Caerulum Pharma Discovery Co., Ltd.