(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
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- $32 - $2400
- Product name: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
- CAS: 2040291-27-6
- MF: C17H18N4O4
- MW: 342.35
- EINECS:
- MDL Number:MFCD31657362
- Synonyms:(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol;LLY-283;LM-5179;LLY-283 (LLY283);7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-;LLY-283 >=98% (HPLC);7-[(5R)-5-CPhenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
12 prices
Selected condition:
Brand
- AK Scientific
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3430EH
- Product descriptionCID122669401
- Packaging25mg
- Price$606
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBL166665
- Product descriptionLLY 283
- Packaging100mg
- Price$1950
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21596
- Product descriptionLLY-283
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030144
- Product descriptionLLY-283 99.04%
- Packaging100mg
- Price$940
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21240
- Product descriptionLLY-283 >98%
- Packaging250mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21240
- Product descriptionLLY-283 >98%
- Packaging1g
- Price$2400
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 3430EH | CID122669401 | 25mg | $606 | 2021-12-16 | Buy |
Biosynth Carbosynth | BL166665 | LLY 283 | 100mg | $1950 | 2021-12-16 | Buy |
Cayman Chemical | 21596 | LLY-283 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21596 | LLY-283 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 21596 | LLY-283 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 21596 | LLY-283 | 25mg | $456 | 2024-03-01 | Buy |
ChemScene | CS-0030144 | LLY-283 99.04% | 5mg | $90 | 2021-12-16 | Buy |
ChemScene | CS-0030144 | LLY-283 99.04% | 10mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0030144 | LLY-283 99.04% | 50mg | $540 | 2021-12-16 | Buy |
ChemScene | CS-0030144 | LLY-283 99.04% | 100mg | $940 | 2021-12-16 | Buy |
DC Chemicals | DC21240 | LLY-283 >98% | 250mg | $1200 | 2021-12-16 | Buy |
DC Chemicals | DC21240 | LLY-283 >98% | 1g | $2400 | 2021-12-16 | Buy |
Properties
Boiling point :688.9±55.0 °C(Predicted)
Density :1?+-.0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 60 mg/ml; Ethanol: 60 mg/ml
form :A crystalline solid
pka :12.46±0.70(Predicted)
color :White to off-white
Density :1?+-.0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 60 mg/ml; Ethanol: 60 mg/ml
form :A crystalline solid
pka :12.46±0.70(Predicted)
color :White to off-white
Safety Information
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Description
LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 μM. It reduces symmetric demethylation of SmBB'' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric, hematological, lung, skin, and ovarian cancer cell lines (IC50s = 3-30 nM). LLY-283 (20 mg/kg) inhibits tumor growth in an A375 mouse xenograft model. It also disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells and increases survival in an orthotopic patient-derived xenograft (PDX) mouse model. See the Structural Genomics Consortium (SGC) website for more information.Suppliers and manufacturers
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
NewCan Biotech Limited
InvivoChem
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Amadis Chemical Company Limited
BOC Sciences
ShangHai Caerulum Pharma Discovery Co., Ltd.