E3 ligase Ligand-Linker Conjugates 5
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- $149 - $1700
- Product name: E3 ligase Ligand-Linker Conjugates 5
- CAS: 2097971-11-2
- MF: C30H46ClN5O7S
- MW: 656.24
- EINECS:
- MDL Number:MFCD31656714
- Synonyms:(S,R,S)-AHPC-PEG3-NH2 hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;E3 ligase Ligand-Linker Conjugates 5;VH032-PEG3-NH2 hydrochloride;VHL Ligand-Linker Conjugates 1 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride >=95%;(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
7 prices
Selected condition：
Brand
- CSNpharm
- DC Chemicals
- Iris Biotech GmbH
- Sigma-Aldrich
Package
- 002
- 003
- 50mg
- 25mg
- 100mg
- 001
- ManufacturerCSNpharm
- Product numberCSN23963
- Product descriptionVHL032-keto-PEG3-C2-amine HCl
- Packaging25mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN23963
- Product descriptionVHL032-keto-PEG3-C2-amine HCl
- Packaging100mg
- Price$326
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product number027599
- Product description(S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
- Packaging001
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product number027599
- Product description(S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
- Packaging002
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product number027599
- Product description(S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
- Packaging003
- Price$1700
- Updated2021-12-16
- Buy
- ManufacturerIris Biotech GmbH
- Product numberPTC1330
- Product description(S,R,S)-AHPC-PEG3-NH2 hydrochloride
- Packaging50mg
- Price$499.5
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number901511
- Product description(S,R,S)-AHPC-PEG3-NH2 hydrochloride ≥95%
- Packaging50mg
- Price$326
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| CSNpharm | CSN23963 | VHL032-keto-PEG3-C2-amine HCl | 25mg | $149 | 2021-12-16 | Buy |
| CSNpharm | CSN23963 | VHL032-keto-PEG3-C2-amine HCl | 100mg | $326 | 2021-12-16 | Buy |
| DC Chemicals | 027599 | (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5） | 001 | $500 | 2021-12-16 | Buy |
| DC Chemicals | 027599 | (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5） | 002 | $850 | 2021-12-16 | Buy |
| DC Chemicals | 027599 | (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5） | 003 | $1700 | 2021-12-16 | Buy |
| Iris Biotech GmbH | PTC1330 | (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 50mg | $499.5 | 2021-12-16 | Buy |
| Sigma-Aldrich | 901511 | (S,R,S)-AHPC-PEG3-NH2 hydrochloride ≥95% | 50mg | $326 | 2024-03-01 | Buy |
Properties
storage temp. :2-8°C
form :powder or crystals
color :Light yellow to brown
form :powder or crystals
color :Light yellow to brown
Safety Information
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Description
Protein degrader builiding block (S,R,S)-AHPC-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Suppliers and manufacturers
TargetMol Chemicals Inc.
Shanghai UCHEM Inc.
Shanxi Tihondan Pharmaceutical Technology Co., Ltd
Aladdin Scientific
ChemShuttle, Inc.
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Sigma-Aldrich
Shanghai Chaolan Chemical Technology Center
Xi'an Confluore Biological Technology Co., Ltd.
