6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
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- $153 - $2033.85
- Product name: 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
- CAS: 226907-52-4
- MF: C15H17N5O3
- MW: 315.33
- EINECS:
- MDL Number:MFCD21337856
- Synonyms:6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol;6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one;CL087;SM360320;Toll-Like Receptor 7 Ligand II;8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-;SM-360320?(Synonyms: CL-087);1V136
5 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
- Matrix Scientific
Package
- 500μg
- 1mg
- 5MG
- 250MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014408
- Product description6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL 95.00%
- Packaging5MG
- Price$495.23
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014408
- Product description6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL 95.00%
- Packaging250MG
- Price$2033.85
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17228
- Product descriptionToll-Like Receptor 7 Ligand II ≥98%
- Packaging500μg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17228
- Product descriptionToll-Like Receptor 7 Ligand II ≥98%
- Packaging1mg
- Price$290
- Updated2024-03-01
- Buy
- ManufacturerMatrix Scientific
- Product number093250
- Product description6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol 95+%
- Packaging250mg
- Price$1286
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0014408 | 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL 95.00% | 5MG | $495.23 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014408 | 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL 95.00% | 250MG | $2033.85 | 2021-12-16 | Buy |
| Cayman Chemical | 17228 | Toll-Like Receptor 7 Ligand II ≥98% | 500μg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 17228 | Toll-Like Receptor 7 Ligand II ≥98% | 1mg | $290 | 2024-03-01 | Buy |
| Matrix Scientific | 093250 | 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol 95+% | 250mg | $1286 | 2021-12-16 | Buy |
Properties
Density :1.356
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form :A crystalline solid
color :White to off-white
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form :A crystalline solid
color :White to off-white
Safety Information
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Description
A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells. It induces IFNα in human peripheral blood mononuclear cells with an EC50 value of 0.14 μM. At 10 μM, TLR7 ligand II was shown to reduce HCV levels by 60% in 24 hours in the human hepatocyte cell line Huh7, which carries a HCV replicon. It induces IFN in mice with a minimal effective dose of approximately 0.03 mg/kg, making it approximately 100-fold more potent than imiquimod .Suppliers and manufacturers
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