Fluorinated VHL Spy Molecule 2
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- $120 - $440
- Product name: Fluorinated VHL Spy Molecule 2
- CAS: 2290526-27-9
- MF: C14H14BrF3N2O3
- MW: 395.17
- EINECS:
- MDL Number:MFCD32672269
- Synonyms:Fluorinated VHL Spy Molecule 2;2-Pyrrolidinecarboxamide, N-[(4-bromophenyl)methyl]-4-hydroxy-1-(2,2,2-trifluoroacetyl)-, (2S,4R)-;(2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand
2 prices
Selected condition：
Brand
- Sigma-Aldrich
Package
- 10mg
- 100mg
- ManufacturerSigma-Aldrich
- Product number909432
- Product descriptionFluorinated VHL Spy Molecule 2 ≥98%
- Packaging10mg
- Price$120
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product number909432
- Product descriptionFluorinated VHL Spy Molecule 2 ≥98%
- Packaging100mg
- Price$440
- Updated2023-06-20
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 909432 | Fluorinated VHL Spy Molecule 2 ≥98% | 10mg | $120 | 2023-06-20 | Buy |
| Sigma-Aldrich | 909432 | Fluorinated VHL Spy Molecule 2 ≥98% | 100mg | $440 | 2023-06-20 | Buy |
Properties
Boiling point :624.2±55.0 °C(Predicted)
Density :1.637±0.06 g/cm3(Predicted)
pka :13.62±0.40(Predicted)
Density :1.637±0.06 g/cm3(Predicted)
pka :13.62±0.40(Predicted)
Safety Information
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Description
Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.